磁化传递成像评估原发性骨质疏松症的价值  

The Value of Magnetization Transfer Imaging in the Evaluation of Primary Osteoporosis

作　　者：谭辉 杨震 樊秋菊 于楠 杨创勃 于勇 王少彧 李悦 TAN Hui;YANG Zhen;FAN Qiuju;YU Nan;YANG Chuangbo;YU Yong;WANG Shaoyu;LI Yue(Department of Radiology,The Affiliated Hospital,Shaanxi University of Chinese Medicine;Institute of Medical Technology,Shaanxi University of Chinese Medicine;MR Senior Scientific Marketing Specialist,Siemens Healthineers,China)

机构地区：[1]陕西中医药大学附属医院医学影像科 [2]陕西中医药大学基础医学与医学技术学院 [3]西门子医疗系统有限公司磁共振科研部

出　　处：《中国医学计算机成像杂志》2022年第1期68-72,共5页Chinese Computed Medical Imaging

基　　金：陕西中医药大学附属医院2020年度院级科研项目(2020QN015);陕西中医药大学学科创新团队建设项目(2019⁃QN09)。

摘　　要：目的:探讨磁化传递成像(MTI)定量评估原发性骨质疏松症的应用价值。方法:回顾性分析159例行腰椎MR检查患者的资料,根据定量CT(QCT)结果分成骨质疏松组、骨量减低组和骨量正常组3组。测量腰2~4椎体磁化传递率(MTR)。比较组间MTR值的差异,绘制ROC曲线以分析MTR对骨质疏松及骨量减低的诊断效能。结果:随着骨密度的降低,椎体MTR值也减低,差异有统计学意义(P<0.001)。MTR值诊断骨量减低与骨质疏松的ROC曲线下面积(AUC)分别为0.875、0.944,MTR阈值分别为10.45、5.95,其诊断骨量减低、骨质疏松的灵敏度分别为78.90%、86.41%,特异度分别为86.84%、89.83%(P<0.001)。结论:MTI技术可以早期、灵敏地检测骨量变化,MTR值可作为骨质疏松症进展的生物学标志物。Purpose:To explore the application value of magnetization transfer imaging(MTI)in quantitative assessment of primary osteoporosis.Methods:The data of 159 subjects who underwent lumbar magnetic resonance examination were retrospectively analyzed and divided into three groups including osteoporosis group,osteopenia group,and normal bone mineral density(BMD)group based on quantitative CT(QCT)examination.The magnetization transfer rate(MTR)value of lumbar vertebrae 2-4 was measured.The differences of MTR values among the three groups were compared.The ROC curve was drawn to analyze the diagnostic performance of MTR for osteoporosis and osteopenia.Results:With the decrease of BMD,the MTR of vertebral body decreased,and the difference was statistically significant(P<0.001).The area under the ROC curve(AUC)of the diagnostic osteopenia and osteoporosis were 0.875 and 0.944,respectively,and the MTR thresholds were 10.45 and 5.95,respectively,and the sensitivity of the diagnosis of osteopenia and osteoporosis was 78.90%,86.41%,and the specificity was 86.84%,89.83%,respectively(P<0.001).Conclusion:MTI can sensitively reflect the change of bone mass in the early stage,and MTR value can be used as a biomarker of the progress of osteoporosis.

关 键 词：磁化传递成像 骨质疏松症 骨密度 腰椎 

分 类 号：R445.2[医药卫生—影像医学与核医学]