江苏省SARS-CoV-2 Delta变异株引起的COVID-19的流行病学特征  

Epidemiological characteristics of SARS-CoV-2 Delta variant infections in Jiangsu Province,China

作　　者：魏艳秋 何薇 孙伟 王新民[3] 吴超杰 张明顺[4] 黄茂 吉宁飞 WEI Yanqiu;HE Wei;SUN Wei;WANG Xinmin;WU Chaojie;ZHANG Mingshun;HUANG Mao;JI Ningfei(Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029;Department of Respiratory and Critical Care Medicine,Xishan People’s Hospital of Wuxi City,Wuxi 214105;Department of Respiratory and Critical Care Medicine,Shuyang Hospital of Traditional Chinese Medicine,Suqian 223699;Department of Immunology,Key Laboratory of Antibody Techniques,National Health Commission,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]南京医科大学第一附属医院呼吸与危重症医学科,江苏南京210029 [2]无锡市锡山人民医院呼吸与危重症医学科,江苏无锡214105 [3]沭阳县中医院呼吸与危重症医学科,江苏宿迁223699 [4]南京医科大学免疫学系,国家卫生健康委员会抗体技术实重点验室,江苏南京211166

出　　处：《南京医科大学学报（自然科学版）》2022年第2期245-251,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省重点研发计划(BE2020616)。

摘　　要：目的:对江苏省由严重急性呼吸综合征冠状病毒2(severe acute respiratory syndromecoronavirus 2,SARS-CoV-2)Delta变异株引起的新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)的流行病学特征进行分析总结。方法:通过在江苏省南京市及扬州市卫生健康委员会官方网站及官方公众号收集江苏省2021年7月20日—8月28日COVID-19本土病例的相关数据,进行流行病学特征分析。结果:江苏省SARS-CoV-2 Delta变异株引起的COVID-19病例累计报告820例,病死率为0。其中,男341例(41.6%),中位年龄为48岁,<20岁111例(13.6%)。轻型、普通型、重型病例的中位年龄差异有统计学意义(P<0.05)。中位潜伏期为9.5(7.5,11.0)d。中位代际间隔为3(2,5)d,一代至二代与二代至三代、二代至三代与三代至四代的代际间隔差异有统计学意义(P<0.05)。首次核酸检测灵敏度为77.7%。此次疫情共发生3起"超级传播者"事件。结论:SARS-CoV-2Delta变异株传染性强,传播速度快,各年龄段人群普遍易感,且有年轻化趋势,重型常见于老年人。建议中高风险地区对于有发热、咳嗽等症状的患者多次测核酸以降低假阴性风险。Objective:This study aims to analyze the epidemiological characteristics of the outbreak caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Delta variant in Jiangsu Province and to provide scientific basis for epidemic prevention and control.Methods:The coronavirus disease 2019(COVID-19)data,reported from July 20 to August 28 in Jiangsu Province,such as basic information,epidemiological history,date of diagnosis,was collected for statistical descriptive analysis.Results:During periods of investigation time,there were 820 cases in Jiangsu Province,and the fatality rate was of all cases 0.Of all cases 0.341(41.6%)were male.The median age was 48 years.At the time of diagnosis,differences of the median age between mild,moderate and severe cases were statistically significant(P<0.05).The median incubation period was 9.5(7.5,11)days.The median serial interval was 3(2,5)days.Differences in serial intervals between 1 stto 2 ndand 2 ndto 3 rdgeneration were statistically significant(P<0.001),2 ndto 3 rdand 3 rdto 4 thgeneration were statistically significant(P<0.05).The sensitivity of the first nucleic acid testing was 77.7%.Thee were 3 super communicators in the epidemic.Conclusion:The SARS-CoV-2 Delta variant is with high transmissibility and spreads rapidly.All age groups are susceptible the Delta variant,and the age was trending younger.Severe cases are more likely to occur in the elderly.Multiple nucleic acid tests are recommended for patients with fever,cough and other symptoms in medium-high risk areas.

关 键 词：Delta变异株 新型冠状病毒肺炎 流行病学特征 

分 类 号：R563.1[医药卫生—呼吸系统]