瓜蒌薤白半夏汤合温胆汤治疗不稳定性心绞痛的疗效  

Effect of Gualouxiebaibanxia Decoction and Wendan Decoction on Unstable Angina Pectoris

作　　者：张明妍[1] 白发臣[1] 张燕 ZHANG Ming-yan;BAI Fa-chen;ZHANG Yan(Sanming Hospital of Integrated Traditional Chinese and Western Medicine,Fujian Sanming 365000)

机构地区：[1]三明市中西医结合医院,福建三明365000

出　　处：《深圳中西医结合杂志》2021年第23期56-58,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨对不稳定性心绞痛患者,应用瓜蒌薤白半夏汤合温胆汤加减治疗效果。方法:选取三明市中西医结合医院2017年1月至2020年10月期间收治的97例痰浊闭阻型不稳定性心绞痛患者,随机分为观察组(49例)与对照组(48例)。对照组给予单硝酸异山梨酯缓释片、阿司匹林肠溶片、氯吡格雷片、阿托伐他汀钙片、低分子肝素钙、发作时舌下含服硝酸甘油等常规药物治疗。观察组在常规药物基础上增加中药汤剂治疗,比较两组患者的治疗效果。结果:治疗后观察组患者的每周含服硝酸甘油用量和每天发作的次数较对照组降低,每次持续时间较对照组缩短,一氧化氮(NO)、前列环素(PGI2)高于对照组,内皮素–1(ET–1)低于对照组,三酰甘油(TG)、胆固醇(CHOL)、低密度脂蛋白胆固醇(LDL–C)低于对照组,高密度脂蛋白胆固醇(HDL–C)高于对照组,观察组患者的治疗总有效率高于对照组;组间比较,差异均具有统计学意义(P<0.05)。结论:对不稳定型心绞痛患者实施常规药物联合使用中药汤剂(瓜蒌薤白半夏汤合温胆汤)治疗,可减少患者含服硝酸甘油用量及疾病发作次数,改善临床指标,提升治疗效果。Objective To explore the effect of Gualouxiebaibanxia Decoction and Wendan Decoction in the treatment of unstable angina pectoris.Methods A total of 97 patients with turbidities and obstructive unstable angina pectoris treated in Sanming Hospital of Integrated Traditional Chinese and Western Medicine from January 2017 to October 2020 were randomly divided into observation group(49 cases)and control group(48 cases).The control group received isosorbide mononitrate sustained release tablets,aspirin enteric-coated tablets,clopidogrel tablets,atorvastatin calcium tablets,low molecular weight heparin calcium,sublingual nitroglycerin and other conventional drug treatment.The observation group was treated with traditional Chinese medicine decoction on the basis of conventional drugs,and the therapeutic effects of the two groups were compared.Results After treatment,the weekly dosage of nitroglycerin and the number of attacks per day in the observation group were lower than those in the control group,and the duration of each attack was shorter than that in the control group.The levels of nitric oxide(NO)and prostacyclin(PGI2)were higher than those in the control group,and the level of endothelin-1(ET-1)was lower than that in the control group.Triglyceride(TG),cholesterol(CHOL),low density lipoprotein cholesterol(LDL-C)were lower than those in the control group,while high density lipoprotein cholesterol(HDL-C)was higher than that in the control group.The effective rate of the observation group was higher than that of the control group.The differences between groups were statistically significant(P<0.05).Conclusion Conventional medicine combined with Traditional Chinese medicine decoction(Gualouxiebaibanxia Decoction and Wendan Decoction)for the treatment of unstable angina pectoris can reduce the dosage of nitroglycerin and the frequency of attack,improve the clinical indicators and improve the therapeutic effect.

关 键 词：不稳定性心绞痛 瓜蒌薤白半夏汤 温胆汤 

分 类 号：R541[医药卫生—心血管疾病]