慢性子宫内膜炎合并不孕症患者CD138表达及其与妊娠结局相关性研究  

Study on the Expression of CD138 in Patients with Chronic Endometritis and Infertility and its Correlation with Pregnancy Outcome

作　　者：冯菊香[1] 倪明军 邱淑琴[1] FENG Ju-xiang;NI Ming-jun;QIU Shu-qin(Huizhou City Huiyang District Maternal and Child Health Care Hospital,Guangdong Huizhou 516001)

机构地区：[1]惠州市惠阳区妇幼保健院,广东惠州516001

出　　处：《深圳中西医结合杂志》2021年第23期74-76,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：惠州市科技计划项目资助课题(2019Y297)。

摘　　要：目的:探究膜硫酸乙酰肝素蛋白多糖配体蛋白聚糖–1(CD138)在慢性子宫内膜炎所致不孕症患者中的阳性表达情况,并探究其对慢性子宫内膜炎致不孕症患者妊娠结局的预测价值。方法:选取惠州市惠阳区妇幼保健院2019年5月至2021年1月期间收治的80例不孕症患者,所有患者均进行子宫内膜活检,根据其子宫内膜苏木精–伊红染色法(HE)染色结果分为病例组22例和阴性组58例。两组患者均进行子宫内膜CD138免疫组化检查,比较各组CD138阳性率。同时对病例组患者予以规范的抗菌药物治疗,两组患者均随访6个月以上追踪受孕成功情况,并分析受孕成功者CD138阳性率。结果:病例组CD138阳性率为95.45 %,显著高于阴性组的3.45 %,差异具有统计学意义(P<0.05)。随访6个月以上,病例组患者经规范抗感染治疗后有3例宫内妊娠,阴性组患者经治疗后有21例宫内妊娠,其中CD138阳性者受孕成功率显著低于CD138阴性者,差异具有统计学意义(P<0.05)。结论:慢性子宫内膜炎合并不孕症患者的子宫内膜CD138阳性率高,且CD138阳性表达的慢性子宫内膜炎合并不孕患者其宫内妊娠成功率低,因此临床有望可通过检测CD138诊断慢性子宫内膜炎合并不孕,并预测其妊娠结局,为临床治疗提供指导。此外,积极治疗子宫内膜炎,使CD138由阳性转为阴性有利于提高妊娠成功率。Objective To explore the positive expression of CD138 in infertility patients caused by chronic endometritis and its predictive value for pregnancy outcome of infertility patients caused by chronic endometritis.Methods 80 infertility patients treated at Huizhou Huiyang Maternal and Child Health Hospital from May 2019 to January 2021 were selected.All patients underwent endometrial biopsy and were divided into case group with 22 cases and negative group with 58 cases.According to the results of endometrial hematoxylin eosin staining.Immunohistochemical examination of CD138 in endometrium was performed in both groups,and the positive rate of CD138 in each group was compared.At the same time,the patients in the case group were treated with standardized antibiotics.The patients in both groups were followed up for more than 6 months,followed up the success of pregnancy,and analyzed the positive rate of CD138 in the successful pregnancy.Results The positive rate of CD138 in case group was 95.45%,which was significantly higher than that in negative group 3.45%,the difference was statistically significant(P < 0.05).Follow-up for more than 6 months,there were 3 cases of intrauterine pregnancy in the case group after standard anti-infection treatment,and 21 cases of intrauterine pregnancy in the negative group after treatment,among which the pregnancy success rate of CD138-positive patients was significantly lower than that of CD138-negative patients,the difference was statistically significant (P < 0.05).Conclusion The positive rate of CD138 in endometrium of patients with chronic endometritis complicated with infertility is high,and the success rate of intrauterine pregnancy of patients with chronic endometritis complicated with infertility with positive expression of CD138 is low.Therefore,it is expected to diagnose chronic endometritis complicated with infertility by detecting CD138,predict its pregnancy outcome,and provide guidance for clinical treatment.In addition,actively treating endometritis and turning CD138 fro

关 键 词：慢性子宫内膜炎 不孕症 膜硫酸乙酰肝素蛋白多糖配体蛋白聚糖–1 

分 类 号：R711.32[医药卫生—妇产科学]