基于加权TOPSIS法的硫酸多黏菌素B药物利用评价  

Drug use evaluation of polymyxin B sulphas for injection based on weighted TOPSIS method

作　　者：王桂凤[1] 李雪芹[1] 刘锐锋[1] 廖础欣[1] 钟婉柔 WANG Gui-feng;LI Xue-qin;LIU Rui-feng;LIAO Chu-xin;ZHONG Wan-rou(Department of Pharmacy,Zhongshan Municipal People’s Hospital,Guangdong Zhongshan 528403,China;School of Pharmacy,Guangdong Pharmaceutical University,Guangdong Zhongshan 528403,China)

机构地区：[1]中山市人民医院药学部,广东中山528403 [2]广东药科大学药学院,广东中山528403

出　　处：《中国医院药学杂志》2022年第3期324-328,共5页Chinese Journal of Hospital Pharmacy

基　　金：中山市科技局课题(编号:2018B1093)。

摘　　要：目的:基于加权优劣解距离法(TOPSIS)对注射用硫酸多黏菌素B的临床使用进行评价,为其合理应用提供参考依据。方法:以注射用硫酸多黏菌素B的药品说明书为基础,参照多黏菌素B相关专家共识等,建立基于加权TOPSIS法的硫酸多黏菌素B药物利用评价细则,以此为依据,对中山市人民医院2018年1月—2020年12月期间77例住院患者硫酸多黏菌素B的使用情况进行评价。结果:评价的77份病历中,与最优方案相对接近程度(C_(i))介于80%~90%的31例(占比40.2%),介于70%~80%的27例(占比35.1%),介于60%~70%的17例(占比22.1%),C_(i)在50%~60%的2例(占比2.60%)。结论:通过基于加权TOPSIS法的硫酸多黏菌素B药物利用评价,可以发现多黏菌素B使用存在的问题,药学部门后续可进行针对性药学干预,促进其合理使用。OBJECTIVE To establish the detailed rules for the utilization evaluation of polymyxin B sulphas for injection,and evaluate the use of polymyxin B sulphas by using the weighted technique for order preference by similarity to ideal solution(TOPSIS)to provide reference for its clinical rational application.METHODS Based on polymyxin B sulphas for injection instructions,referring to the consensus of experts on polymyxin B,and according to the weighted TOPSIS method,the evaluation rules of polymyxin B sulphas for injection were established.Based on this,the use of polymyxin B sulphas for injection in 77 inpatients of a hospital from January 2018 to December 2020 was evaluated.RESULTS Among the 77 cases,relative proximity to the optimal scheme of 31 cases(40.2%)was between 80%-90%,that of 27 cases(35.1%)was between 70%-80%,that of 17 cases(22.1%)was between 60%-70%,and that of 2 cases(2.60%)was between 50%-60%.CONCLUSION Through the weighted TOPSIS method for polymyxin B sulphas utilization evaluation,the problems in the use of polymyxini B sulphas can be found,and pharmacy department can carry out targeted pharmaceutical interventions to promote its rational use.

关 键 词：硫酸多黏菌素B 加权TOPSIS法 属性层次模型 药物利用评价 

分 类 号：R969[医药卫生—药理学]