妊娠期糖尿病母亲和婴儿血清25OHD3及其与胰岛素、炎症因子的表达相关性  

Serum 25-hydroxyvitamin D levels of mothers with gestational diabetes mellitus and infants and their association with insulin and inflammatory factors

作　　者：韩雁雁 邱锐琴[1] 乔木[1] 张洁[2] 姚文秀[1] HAN Yanyan;QIU Ruiqin;QIAO Mu;ZHANG Jie;YIAO Wenxiu(Department of Neonatology, Qinhuangdao First Hospital, Qinhuangdao 066000, Hebei, China;Department of Infectious Diseases, Qinhuangdao First Hospital, Qinhuangdao 066000, Hebei, China)

机构地区：[1]秦皇岛市第一医院新生儿科,河北秦皇岛066000 [2]秦皇岛市第一医院感染性疾病科,河北秦皇岛066000

出　　处：《西部医学》2022年第3期453-457,共5页Medical Journal of West China

基　　金：秦皇岛市重点研发计划科技支撑项目(202004A065)。

摘　　要：目的探讨妊娠期糖尿病(GDM)母亲和婴儿血清25-羟维生素D(25OHD3)及其与胰岛素(FINS)、炎症因子的表达相关性。方法收集2017年5月~2020年5月我院收治的629例妊娠妇女为研究对象,根据有无GDM发生分为GDM组(n=62)和非GDM组(n=567),比较两组一般资料和血清25OHD3水平,根据GDM组母亲、婴儿血清25OHD3表达水平分为缺乏组、不足组和充足组。比较各组FINS表达水平和炎症因子[白介素-6(IL-6)、白介素-7(IL-7)、白介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)、血清C反应蛋白(CRP)]、空腹血糖(FPG)表达水平,同时进行相关性分析。结果629例妊娠期妇女共62例发生GDM,GDM占比为9.86%(62/629)。GDM组年龄≥30岁占比明显高于非GDM组,GDM组母亲和婴儿血清25OHD3均明显低于GDM组(P<0.05)。母体:GDM组的缺乏组、不足组和充足组血清FINS依次明显升高,而血清IL-6、IL-7、IL-17、TNF-α、CRP和FBG依次明显降低,且组间两两比较差异有统计学意义(P<0.05)。婴儿:缺乏组a、不足组a和充足组a血清FINS依次明显升高,血清IL-6、IL-7、IL-17、TNF-α、CRP和FPG依次明显降低(P<0.05),而出生后6、24、48 h各组血清IL-6、IL-7、IL-17、TNF-α、CRP无明显变化趋势(P>0.05)。Pearson参数分析提示GDM母体和婴儿血清25OHD3水平与FINS、炎症因子水平存在明显相关性(P<0.05)。结论妊娠期糖尿病母体和婴儿血清25-羟维生素D表达水平明显下降,且妊娠期糖尿病母体和婴儿血清25-羟维生素D表达水平与胰岛素存在明显正相关,而与炎症因子表达水平存在负相关,或可为妊娠期糖尿病的合理防治提供指导。Objective To investigate the serum 25-hydroxyvitamin D(25OHD3)levels in mothers with gestational diabetes mellitus(GDM)and infants,and their association with insulin(FINS)and the expression of inflammatory factors.Methods Totally 629 pregnant women who delivered in department of obstetrics at the hospital from May 2017 to May 2020 were enrolled in the study.The incidence of GDM was counted.According to presence or absence of GDM,the subjects were divided into GDM group and non-GDM group.General data and serum 25OHD3 levels were compared between the two groups.According to the serum 25OHD3 levels in mothers and infants of GDM group,they were divided into deficiency group,insufficiency group and sufficiency group.The levels of FINS and inflammatory factors interleukin-6(IL-6),interleukin-7(IL-7),interleukin-17(IL-17),tumor necrosis factor-α(TNF-α)were compared among groups,and correlation analysis was conducted.Results Of the 629 pregnant women,62 had GDM(9.86%).The proportion of pregnant women not under 30 years old was significantly higher in GDM group than in non-GDM group(P<0.05).Maternal and neonatal serum 25OHD3 levels of the GDM group were significantly lower than those of the non-GDM group(P<0.05).From the maternal aspect,serum FINS significantly increased in turn,while serum IL-6,IL-7,IL-17,TNF-α,CRP,and fasting blood glucose significantly decreased in turn in the deficiency group,insufficiency group and sufficiency group,with significant differences between any two groups(P<0.05).From the infant aspect,serum FINS significantly increased,while serum IL-6,IL-7,IL-17,TNF-α,CRP,and fasting blood glucose significantly decreased in turn in deficiency group a,insufficiency group a and sufficiency group a,with significant differences between any two groups(P<0.05).Serum IL-6,IL-7,IL-17,TNF-αand CRP in each group showed no obvious changes at 6,24,and 48 hours after birth(P>0.05).Pearson analysis indicated that serum 25OHD3 levels of GDM mothers and infants were significantly associated with the levels of FINS

关 键 词：妊娠糖尿病 婴儿 25-羟维生素D 胰岛素 炎症因子 

分 类 号：R714.256[医药卫生—妇产科学]