以手性1-氮杂螺[4.4]壬烷骨架为中间体合成(-)-Cephalotaxine的研究进展  

Research Progress on Synthesis of(-)-Cephalotaxine via Chiral 1-Azaspiro[4.4]nonane Skeleton

作　　者：刘建银 范玉雪 张建 LIU Jian-yin;FAN Yu-xue;ZHANG Jian(School of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, China;Key Laboratory of Chemistry and Quality for TCM of the College of Gansu Province, Lanzhou 730000, China)

机构地区：[1]甘肃中医药大学药学院,甘肃兰州730000 [2]甘肃省高校中(藏)药化学与质量研究省级重点实验室,甘肃兰州730000

出　　处：《合成化学》2022年第3期237-244,共8页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21562001)。

摘　　要：高三尖杉酯碱因具有较好的抗癌和抗肿瘤活性而受到广泛重视,2012年,美国FDA正式批准其用于临床治疗慢性粒白血病适应症。三尖杉碱为高三尖杉酯碱的母核结构,具有5个环系以及3个相邻的手性中心。三尖杉碱分子结构的特殊性以及高三尖杉酯碱良好的药理活性,促使众多研究小组对其展开了不对称合成研究。本文综述了以手性1-氮杂螺[4.4]壬烷骨架为中间体,合成(-)-Cephalotaxine的研究进展。Homoharringtonine has been paid more and more attention because of its good antitumor and antitumor activity.It was approved by the FDA as an adult orphan-drug for the treatment of chronic myeloid leukemia in 2012.Cephalotaxine is the parent structure of Homoharringtonine and has a pentacyclic ring system with three contiguous stereogenic centers.Because the particularity of the molecular structure of Cephalotaxine and the good pharmacological activity of Cephalotaxine,many research groups have carried out asymmetric synthesis of Cephalotaxine.This article summarizes the progress of synthesis of(-)-Cephalotaxine via chiral 1-azaspiro[4.4]nonane skeleton.

关 键 词：高三尖杉酯碱 三尖杉碱 不对称合成 研究进展 综述 天然产物 药理活性 

分 类 号：O62[理学—有机化学] R914.5[理学—化学]