三维石墨烯及其衍生物在牙源性干细胞成骨中的研究进展  

Research Progress of Three-dimensional Graphene and Its Derivatives in Osteogenesis of Dental Stem Cells

作　　者：叶青 李继遥[1] YE Qing;LI Jiyao(State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙体牙髓病科,四川成都610041

出　　处：《口腔医学研究》2022年第3期212-215,共4页Journal of Oral Science Research

基　　金：国家自然科学基金(编号:81991501)。

摘　　要：石墨烯是作为一种新兴材料,在生物医学领域的研究近年来逐渐增多。三维石墨烯是指具有三维结构的二维石墨烯组装体,三维结构提升了石墨烯的多孔性、比表面积等,更适于细胞粘附、生长,使其具有诱导间充质干细胞成骨的能力。本文以三维石墨烯及其衍生物的理化性质和生物相容性为基础,对三维石墨烯及其衍生物诱导牙源性干细胞成骨作用的研究进展作一综述,为在口腔医学领域进一步研究石墨烯成骨应用提供参考和借鉴。Graphene is a novel material with broad applications in many fields.Its research in biomedical field is increasing in recent years.Three-dimensional graphene refers to the two-dimensional graphene assembly with three-dimensional structure.The three-dimensional structure shows better porosity and larger surface area of graphene,which improves the adhesion and growth of cells,making it capable of inducing bone formation of mesenchymal stem cells.Based on the physical and chemical properties and biocompatibility of three-dimensional graphene,this review summarizes the researches on three-dimensional graphene and its derivatives in inducing osteogenesis of dental stem cells,with hope to provide reference for the osteogenesis application of graphene in dental research.

关 键 词：石墨烯 牙源性干细胞 骨组织工程 

分 类 号：TB3[一般工业技术—材料科学与工程]