噻托溴铵联合多索茶碱在慢阻肺患者中的疗效及对呼吸阻抗的影响  

Observation on Effect of Tiotropium Bromide Combined with Doxofylline in Patients with Chronic Obstructive Pulmonary Disease and Its Influence on Respiratory Impedance

作　　者：刘君[1] 张静[1] 徐超 LIU Jun;ZHANG Jing;XU Chao(Rizhao Hospital of Traditional Chinese Medicine,Shandong Province,Rizhao 276800,China;不详)

机构地区：[1]山东省日照市中医医院,山东日照276800 [2]山东省日照市人民医院

出　　处：《中国医学创新》2022年第6期127-130,共4页Medical Innovation of China

摘　　要：目的:探究与观察噻托溴铵联合多索茶碱在慢阻肺患者中的疗效及对呼吸阻抗的影响。方法:选取2019年10月-2021年3月的90例慢阻肺患者为研究对象,将其根据随机数字表法分为对照组和观察组,每组45例。比较两组临床总有效率、治疗前后的慢阻肺评估测试问卷(CAT)评分、肺通气指标及呼吸阻抗指标。结果:观察组治疗2、4周临床总有效率均显著高于对照组,差异均有统计学意义(P<0.05)。两组治疗前CAT评分、肺通气指标及呼吸阻抗指标比较,差异均无统计学意义(P>0.05);观察组治疗2、4周CAT评分、肺通气指标及呼吸阻抗指标均显著优于对照组,差异均有统计学意义(P<0.05)。结论:噻托溴铵联合多索茶碱在慢阻肺患者中的疗效较好,可显著改善患者的呼吸阻抗,因此在慢阻肺患者中的应用价值相对较高。Objective:To investigate and observe the effect of Tiotropium Bromide combined with Doxofylline in the patients with chronic obstructive pulmonary disease and its influence on respiratory impedance.Method:A total of 90 patients with chronic obstructive pulmonary disease from October 2019 to March 2021 were chosen as the study objects,they were divided into the control group and the observation group according to the method of random number table,45 cases in each group.Then the total effective rates,COPD assessment test (CAT) scores,pulmonary ventilation indexes and respiratory impedance indexes before and after treatment of two groups were compared.Result:The total effective rates at 2,4 week after treatment of observation group were significantly higher than those of the control group,there were statistically significant differences (P<0.05).The CAT scores,pulmonary ventilation indexes and respiratory impedance indexes of two groups before treatment were compared,there were no statistically significant differences (P>0.05);the CAT scores,pulmonary ventilation indexes and respiratory impedance indexes of the observation group at 2 and 4 week after treatment were significantly better than those of the control group,there were statistically significant differences (P<0.05).Conclusion:The effect of Tiotropium Bromide combined with Doxofylline in the patients with chronic obstructive pulmonary disease is better,and it can significantly improve the respiratory impedance,so its application value in the patients with chronic obstructive pulmonary disease is relatively higher.

关 键 词：噻托溴铵 慢阻肺 呼吸阻抗 

分 类 号：R563.9[医药卫生—呼吸系统]