血清S-100β、NSE及TCD等指标在脓毒症相关性脑病患者中的变化及意义  

Changes and Significance of Serum S-100β,NSE and TCD in Patients with Sepsis Associated Encephalopathy

作　　者：王晶晶 WANG Jingjing(Jiamusi Central Hospital,Heilongjiang Province,Jiamusi 154002,China)

机构地区：[1]黑龙江省佳木斯市中心医院,黑龙江佳木斯154002

出　　处：《中国医学创新》2022年第5期23-26,共4页Medical Innovation of China

摘　　要：目的:探讨血清S-100β、NSE及TCD等指标在脓毒症相关性脑病(SAE)患者中的变化及意义。方法:选择2019年1月-2021年1月佳木斯市中心医院收治的80例脓毒症患者,其中45例SAE患者为SAE组,35例无SAE的患者为对照组。统计分析两组一般临床资料;于患者入院第1天未治疗时和对症治疗后的第3天检测并记录血清S-100β、NSE水平,同时进行TCD检查,记录并比较两组舒张末期血流速度(Vd)、收缩期峰值血流速度(Vs)、平均血流速度(Vm),通过测得数值计算搏动指数(PI)及阻力指数(RI)。结果:SAE组APACHEⅡ评分、SOFA评分及休克比例均高于对照组(P<0.05)。SAE组入院第1、3天血清NSE、S-100β均明显高于对照组,两组入院第3天血清NSE、S-100β均低于第1天,差异均有统计学意义(P<0.05)。两组入院第1天及第3天的Vs比较,差异均无统计学意义(P>0.05);入院第1、3天,对照组的Vd、PI、RI均优于SAE组,差异均有统计学意义(P<0.05);对照组入院第1天的Vm高于SAE组,差异有统计学意义(P<0.05);两组入院第3天PI、RI均优于入院第1天(P<0.05)。结论:SAE患者病情较重,血清S-100β、NSE及Vd、Vm、PI、RI变化明显,动态监测上述指标变化有助于病情及治疗效果的判断。Objective:To investigate the changes and significance of serum S-100β,NSE and TCD in patients with sepsis associated encephalopathy(SAE).Method:A total of 80 sepsis patients admitted to Jiamusi Central Hospital from January 2019 to January 2021 were selected,including 45 patients with SAE as the SAE group and 35 patients without SAE as the control group.The general clinical data of the two groups were statistically analyzed;serum S-100β,NSE were detected and recorded on the first day of admission without treatment and the third day after symptomatic treatment.The end diastolic blood flow velocity(Vd),peak systolic blood flow velocity(Vs)and mean blood flow velocity(Vm)were recorded and compared between the two groups,the pulsatility index(PI)and resistance index(RI)were calculated by the measured values.Result:The APACHEⅡscore,SOFA score and shock rate of SAE group were higher than those of the control group(P<0.05).Serum NSE and S-100βin SAE group were significantly higher than those in control group on the 1st and 3rd day of admission,and serum NSE and S-100βin SAE group on the 3rd day of admission were lower than those in the 1st day of admission,the differences were statistically significant(P<0.05).There were no significant differences in Vs between the two groups on the 1st and 3rd day of admission(P>0.05);on the 1st and 3rd day of admission,Vd,PI and RI in the control group were better than those in the SAE group,the differences were statistically significant(P<0.05);the Vm of the control group on the 1st day of admission was higher than that of the SAE group,the difference was statistically significant(P<0.05);PI and RI on the 3rd day of admission in both groups were better than those on the 1st day(P<0.05).Conclusion:Patients with SAE are in severe condition,serum S-100β,NSE and Vd,Vm,PI,RI changed significantly in patients with SAE,dynamic monitoring the changes of these indexes is helpful to judge patients condition and therapeutic effect.

关 键 词：脓毒症相关性脑病 S-100Β 神经元特异性烯醇化酶 经颅多普勒超声 

分 类 号：R459.7[医药卫生—急诊医学] R747.9[医药卫生—治疗学]