非瓣膜性心房颤动老年患者用药现状及影响因素分析  

Current medications and influencing factors for senile patients with NVAF

作　　者：柴晓利[1] 张臣 丰庆春 刘欢[2] CHAI Xiaoli;ZHANG Chen;FENG Qingchun;LIU Huan(Department of Cardiology,Hunan Brain Hospital,Changsha Hunan 410015,China;Hunan University of Traditional Chinese Medicine,Changsha Hunan 410015,China)

机构地区：[1]湖南省脑科医院心血管内科,湖南长沙410015 [2]湖南中医药大学,湖南长沙410015

出　　处：《中国药物警戒》2022年第3期302-305,共4页Chinese Journal of Pharmacovigilance

基　　金：湖南省卫生和计划生育委员会项目(B2015-104)。

摘　　要：目的探讨非瓣膜性心房颤动(non-valvular atrial fibrillation,NVAF)老年患者用药现状及对抗凝治疗的影响。方法选取2015年3月1日至2019年3月31日在我市5家三甲医院心血管内科住院NVAF老年患者482例作为研究对象,采用自制问卷调查人口统计学资料,随访记录患者连续使用1个月以上的药物;比较2组间人口统计学资料差异,评价抗栓及多重用药(≥5种用药)治疗现状,采用Logistic分析多重用药的影响因素。结果482例患者中,250例(51.87%)治疗合理,58例(12.05%)治疗过度,37例(7.68%)治疗不足,137例(28.42%)未治疗。482例患者中多重用药234例,非多重用药组248例。Logistic因素回归分析显示,文化程度、医保类型、高血压、糖尿病、冠心病及心力衰竭为多重用药的独立危险因素(P<0.05)。结论老年NVAF患者普遍存在多重用药情况;需提高抗凝治疗的比例。Objective To investigate current medications for elderly patients with non-valvular atrial fibrillation(NVAF)and the effect on anticoagulant therapies.Methods A total of 482 elderly patients with NVAF hospitalized in cardiovascular departments of five big hospitals in Changsha between March 2015 and March 2019 were selected as the subjects.A self-designed questionnaire was used to investigate the demographic data that was compared between the two groups.The usage of antithrombotic therapies and multiple drugs(≥5 drugs)was evaluated,and the influencing factors of multiple drugs were analyzed by logistic regression analysis.Results Among the 482 patients,250(51.87%)were properly treated,58(12.05%)were over-treated,37(7.68%)were undertreated,and 137(28.42%)were left untreated.Logistic regression analysis showed that levels of education,type of medical insurance,hypertension,diabetes,coronary heart disease and heart failure were independent risk factors for multiple drug use(P<0.05).Conclusion Multiple medication is common in elderly NVAF patients,and the proportion of anticoagulant therapies needs to be improved.

关 键 词：老年患病 非瓣膜性心房颤动 多重用药 抗凝治疗 

分 类 号：R969.3[医药卫生—药理学]