头孢曲松钠注射液致透析患者抗生素脑病3 例分析  

Three cases of antibiotic encephalopathy caused by ceftriaxone sodium injection in dialysis patients

作　　者：朱旭婷 任佳 杭永付[2] ZHU Xuting;REN Jia;HANG Yongfu(Department of Pharmacy,the Affiliated Hospital of Jiangnan University,Wuxi Jiangsu 214041,China;Department of Pharmacy,the First Affiliated Hospital of Soochow University,Suzhou Jiangsu 215006,China)

机构地区：[1]江南大学附属医院药学部,江苏无锡214041 [2]苏州大学附属第一医院药学部,江苏苏州215006

出　　处：《中国药物警戒》2022年第3期336-338,共3页Chinese Journal of Pharmacovigilance

摘　　要：目的分析头孢曲松钠在肾内科透析患者中引起的抗生素脑病,为特殊人群临床用药提供参考。方法临床药师根据国家药品不良反应中心制定的关联性评价标准及诺氏药物不良反应评估量表分析了3例由头孢曲松钠引起精神异常症状的透析患者,并对其进行因果关系评价。结果3例患者病程中使用头孢曲松钠后,均出现了不同程度的精神异常症状,停用抗菌药物并予对症处理后,精神症状均得到缓解。结论对于肾功能不全患者,使用头孢菌素类抗菌药物需谨慎,特别是说明书未收载的精神异常症状,偶有发生,需引起医护人员重视,加强临床观察。Objective To analyze antibiotic encephalopathy caused by ceftriaxone sodium in patients under renal dialysis,and to provide reference for clinical drug use among a special population.Methods The clinical data on three dialysis patients with psychiatric symptoms caused by ceftriaxone sodium was analyzed by a clinical pharmacist according to the correlation evaluation criteria established by the National Center for Adverse Drug Reactions and the Naranjo's Adverse Drug Evaluation Scale.Results After ceftriaxone sodium was used,all the three patients experienced different degrees of psychotic symptoms.But when antibacterial drugs were discontinued and symptomatic treatment started,these mental symptoms were alleviated.Conclusion For patients with renal insufficiency,cephalosporins should be used with caution to prevent psychiatric abnormalities that are not included in the instructions,which occasionally occur and need to be taken seriously by clinicians.

关 键 词：头孢曲松钠 慢性肾功能不全 透析 抗生素脑病 

分 类 号：R994.11[医药卫生—毒理学]