初治涂阳肺结核患者糖尿病患病率调查及其临床特点分析  

Prevalence and clinical characteristics of diabetes mellitus in patients with primary smear-positive pulmonary tuberculosis

作　　者：杨铭 袁平 时正雨 陈黎 刘大凤 Yang Ming;Yuan Ping;Shi Zhengyu;Cheng Li;Liu Dafeng(Department of Tuberculosis,Chengdu,Sichuan 610061,China;Department of Internal Medicine,Public Health Clinic Centre of Chengdu,Chengdu,Sichuan 610061,China)

机构地区：[1]成都市公共卫生临床医疗中心结核科,四川成都610061 [2]成都市公共卫生临床医疗中心内科,四川成都610061

出　　处：《现代临床医学》2022年第2期92-94,106,共4页Journal of Modern Clinical Medicine

基　　金：2014年成都市卫生局科研课题(成卫科教[2014]28号)。

摘　　要：目的:了解初治涂阳肺结核患者糖尿病的患病率和临床特点。方法:对我中心2015年1月至2019年12月收治的125例初治涂阳肺结核患者进行口服葡萄糖耐量试验和血糖监测,分析其糖尿病和糖尿病前期的患病率和临床特点。结果:最终纳入研究118例,其中糖尿病组27例、糖尿病前期组30例、血糖正常组61例,3组均以男性居多。合并症中仅糖尿病组与血糖正常组的高血压发生率差异有统计学意义(P<0.05);3组胸部影像表现差异均无统计学意义(P>0.05);3组肺外结核中仅胸膜炎发生率比较差异有统计学意义(P<0.05);糖尿病组耐多药联合泛耐药发生率高于其余两组(P<0.05)。结论:初治涂阳肺结核患者并发糖尿病或糖尿病前期比较普遍,男性多于女性。患糖尿病初治涂阳肺结核患者的高血压、胸膜炎及耐多药发生率更高,要注意在此类人群中进行耐药筛查。Objective:To investigate the prevalence and clinical characteristics of diabetes mellitus in patients with primary smear-positive pulmonary tuberculosis.Methods:Oral glucose tolerance test and blood glucose monitoring were performed in 125 patients with newly diagnosed smear-positive pulmonary tuberculosis admitted to our center from January 2015 to December 2019.The prevalence and clinical characteristics of diabetes mellitus and prediabetes mellitus were analyzed.Results:118 cases were included in the study,including 27 cases in the diabetes group,30 cases in the prediabetes group and 61 cases in the normoglycemia group;most of the patients in the three groups were men.Among the complications,only the incidence of hypertension between the diabetes group and the normoglycemic group had a statistically significant difference(P<0.05);there were no significant differences in chest imaging findings among the three groups(P>0.05);only the incidence of pleurisy in extrapulmonary tuberculosis among the three groups had a statistically significant difference(P<0.05);the incidence of multidrug plus pan-drug resistance in the diabetic group was significantly higher than that in the other two groups(P<0.05).Conclusion:Diabetes mellitus or prediabetes mellitus is common in patients with primary smear-positive pulmonary tuberculosis,and men are more than women.The incidences of hypertension,pleurisy and multidrug resistance in these patients with diabetes mellitus are higher.Therefore,drug resistance screening should be carried out in such populations.

关 键 词：肺结核 糖尿病 临床特点 耐药 

分 类 号：R521[医药卫生—内科学] R587.1[医药卫生—临床医学]