小青龙颗粒联合沙美特罗丙酸氟替卡松干粉对支气管哮喘患者的疗效及血清sCD86、S100A4水平的影响  

Effect of Xiaoqinglong Granule combined with salmeterol and fluticasone propionate dry powder on changes of serum sCD86 and S100A4 levels,act score and immune function in patients with asthma

作　　者：吴艳[1] 董忠尧 沙春梅 WU Yan;DONG Zhongyao;SHA Chunmei(Department of Internal Medicine,Zaozhuang Maternal and Child Health Hospital,Zaozhuang,Shandong 277100,China;Department of Internal Medicine,Mental Health Center of Zaozhuang,Zaozhuang,Shandong 277100,China)

机构地区：[1]山东省枣庄市妇幼保健院内科,山东枣庄277100 [2]山东省枣庄市精神卫生中心内科,山东枣庄277100

出　　处：《国际检验医学杂志》2022年第6期749-753,共5页International Journal of Laboratory Medicine

摘　　要：目的探讨应用小青龙颗粒联合沙美特罗丙酸氟替卡松干粉治疗支气管哮喘患者的临床疗效,对其血清可溶性白细胞分化抗原86(sCD86)、钙离子结合蛋白A4(S100A4)水平的影响。方法选择2019年12月至2020年12月该院收治的64例支气管哮喘急性发作期患者作为研究对象,通过随机数字表法分为研究组和对照组,每组32例。两组患者均给予西医内科常规治疗,对照组在常规治疗的基础上给予沙美特罗丙酸氟替卡松干粉吸入剂吸入治疗,研究组在对照组基础上联合小青龙颗粒口服治疗,均治疗1周。比较两组患者治疗前后血清sCD86、S100A4、肺功能指标、免疫球蛋白水平及哮喘控制测试(ACT)评分变化,综合分析临床疗效。结果研究组治疗有效率为93.75%,明显高于对照组的78.13%(χ^(2)=4.267,P<0.05);治疗后,研究组ACT评分明显高于对照组(t=2.865,P<0.05);治疗后,研究组第1秒用力呼气容积(FEV_(1))、最大呼气流量(PEF)高于对照组(t=3.012、2.369,P<0.05);治疗后,研究组患者IgA、IgG水平明显高于对照组(t=4.588、3.639,P<0.05);治疗后,研究组血清sCD86及S100A4水平明显低于对照组(t=2.744、11.724,P<0.05);两组患者在治疗期间均未出现明显不良反应,血常规、肝肾功能及凝血指标等检查均未见异常。结论小青龙颗粒联合沙美特罗氟替卡松可有效改善支气管哮喘急性发作期患者的临床症状,改善患者肺功能和免疫功能,降低血清sCD86及S100A4水平,且安全性较高,值得临床推广应用。Objective To investigate the clinical effect of Xiaoqinglong Granule combined with salmeterol fluticasone propionate dry powder in the treatment of bronchial asthma,and to analyze the influence on serum soluble cluster of differentiation 86(sCD86)and calcium ion binding protein A4(S100A4)levels.Methods A total of 64 patients who were admitted to our hospital during the period from December 2019 to December 2020 during the acute attack of bronchial asthma were prospectively included as research subjects.They were divided into a research group and a control group,32 cases in each group.Patients in the two groups were given routine treatment in internal medicine of Western medicine.On the basis of routine treatment,patients in the control group were given salmeterol and fluticasone propionate dry powder inhalation treatment.On the basis of control group,patients in the research group were given oral treatment with Xiaoqinglong Granule.All the patients were treated for one week.The serum sCD86 and S100A4 levels,lung function changes,immunoglobulin levels and the asthma control test(ACT)score changes of the two groups before and after treatment were compared to comprehensively analyze the clinical efficacy.Results The effective rate of research group was 93.75%,which was significantly higher than that of the control group(78.13%)(χ^(2)=4.267,P<0.05).After treatment,the ACT scores of the research group was significantly higher than that of the control group(t=2.865,P<0.05).After treatment,FEV_(1) and PEF of the research group were significantly higher than those in the control group(t=3.012,2.369,P<0.05).After treatment,the IgA and IgG levels of patients in the research group was significantly higher than that in the control group(t=4.588,3.639,P<0.05).After treatment,serum sCD86 and S100A4 levels in the research group were significantly lower than those in the control group(t=2.744,11.724,P<0.05).Patients in both groups didn′t have obvious adverse reactions during the treatment,and no abnormality was found in routi

关 键 词：小青龙颗粒 支气管哮喘 可溶性白细胞分化抗原86 钙离子结合蛋白A4 哮喘控制测试评分 

分 类 号：R562.2[医药卫生—呼吸系统]