丁氟螨酯及其代谢物对大型溞的毒性效应  

Acute toxicity of cyflumetofen and its metabolites to Daphnia magna Straus

作　　者：安雪花[1] 李冬雪 代德茂 余世锋 赵美芹 吴声敢[1] 赵学平[1] AN Xuehua;LI Dongxue;DAI Demao;YU Shifeng;ZHAO Meiqin;WU Shenggan;ZHAO Xueping(Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021,China;Beijing Great-Agri Institute of Pesticide Technology,Beijing 100016, China;Beijing Kefa Weiye Technology Limited Company, Beijing 100125, China)

机构地区：[1]浙江省农业科学院农产品质量安全与营养研究所,浙江杭州310021 [2]北京大农时代农药技术研究所,北京100016 [3]北京科发伟业技术有限公司,北京100125

出　　处：《浙江农业学报》2022年第3期557-565,共9页Acta Agriculturae Zhejiangensis

摘　　要：为评价丁氟螨酯及其代谢物[A-2、AB-1 dimer、AB-1、AB-11、B-1、B-3、Target 1(B-2)、Met-1]对水生生物的生态风险,采用半静态法测定丁氟螨酯及其8种代谢物对大型溞48 h暴露的急性毒性效应,以及丁氟螨酯对大型溞的21 d慢性毒性效应。结果表明:丁氟螨酯、Target 1(B-2)和Met-1对大型溞的48 h-EC_(50)(半数抑制浓度)分别为>0.0115、>0.0315、>0.0328 mg·L^(-1),在溶解度范围内对大型溞的活动无影响;B-1和B-3对大型溞的48 h-EC_(50)均大于133 mg·L^(-1),属于低毒;A-2、AB-1 dimer、AB-1、AB-11的48 h-EC_(50)分别为7.20、0.000127、1.71、0.316 mg·L^(-1),分别属于中毒、剧毒、中毒和高毒。丁氟螨酯对大型溞的21 d无可观察效应浓度(NOEC)大于0.0178 mg·L^(-1),说明其在溶解度范围内对大型溞的生长和繁殖无显著抑制效应。基于48 h-EC_(10)(10%抑制浓度)和48 h-EC_(50)计算急慢性毒性比(ACR),A-2、AB-1 dimer、AB-1、AB-11的ACR值范围为0.235~1.60,远小于推荐值(100)。综上,丁氟螨酯在溶解度范围内对大型溞无明显的急性毒性和慢性毒性,但代谢物中的A-2、AB-1 dimer、AB-1和AB-11会抑制大型溞急性活动,其环境风险不容忽视。研究结果可为丁氟螨酯的水生态风险评价和该类农药的合理安全使用提供基础数据。To evaluate the risk of cyflumetofen and its metabolites on aquatic organisms,acute toxicities of cyflumetofen and its metabolites[A-2,AB-1 dimer,AB-1,AB-11,B-1,B-3,Target 1(B-2),Met-1]on Daphnia magna Straus within 48 h were carried out by semi-static tests,and chronic toxicities of cyflumetofen on D.magna were also investigated by 21 d exposure tests.It was shown that the 48h-EC_(50)(50%inhibitory concentration)of cyflumetofen,Target 1(B-2)and Met-1 on D.magna were>0.0115,>0.0315,>0.0328 mg·L^(-1),respectively,indicating that these reagents had no effect on the activity of D.magna in the concentration range of solubility.The 48 h-EC_(50) of B-1 and B-3 were both higher than 133 mg·L^(-1),indicating low toxicity.The 48 h-EC_(50) of A-2,AB-1 dimer,AB-1 and AB-11 were 7.20,0.000127,1.71,0.316 mg·L^(-1),respectively,indicating medium toxicity,very high toxicity,medium toxicity and high toxicity.The no observable effect concentration(NOEC)of D.magna continuously exposed for 21 d was less than 0.0178 mg·L^(-1),indicating that the cyflumetofen had no significant inhibitory effect on the growth and reproduction of D.magna in the maximum solubility.Based on 48 h-EC_(10)(10%inhibitory concentration)and 48 h-EC_(50),the acute-chronic toxicity ratio(ACR)was calculated.The determined ACRs of A-2,AB-1 dimer,AB-1 and AB-11 ranged from 0.235 to 1.60,which were much lower than the recommended values(100).In conclusion,cyflumetofen within the maximum solubility had no acute and chronic toxic effects on D.magna,but its metabolites A-2,AB-1 dimer,AB-1 and AB-11 had adverse effects,of which the environmental risk should never be neglected.The present results provided scientific basis for the assessment of aquatic environment risk and safe use of cyflumetofen.

关 键 词：丁氟螨酯 大型溞 急性毒性 慢性毒性 

分 类 号：S481.8[农业科学—农药学]