115例药物致肝脏药品不良反应分析  

115 cases of drug-related adverse reactions in the liver

作　　者：吕娟 郭未艳[1] 王园姬 李亚美 王颖丽[1] 段石顽 LYU Juan;GUO Weiyan;WANG Yuanji;LI Yamei;WANG Yingli;DUAN Shiwan(Department of Pharmacy,Xi’an NO.1 Hospital,Xi’an Shaanxi 710002,China)

机构地区：[1]西安市第一医院药剂科,陕西西安710002

出　　处：《中国药物警戒》2022年第2期200-204,共5页Chinese Journal of Pharmacovigilance

摘　　要：目的了解药物致肝脏相关不良反应的发生情况及临床特点,为临床用药提供参考。方法采用回顾性分析方法,运用医院信息管理系统,收集西安市第一医院2016年1月1日至2019年12月31日药物致肝脏相关不良反应病例115例。对患者一般资料、生化指标、临床分型、损伤程度、涉及药品、不良反应发生时间、临床转归及治疗药物情况等进行统计分析。结果男性50例,女性65例,平均年龄(57.98±16.64)岁。药物导致肝脏不良反应多发生在服药后3个月内(74例,62.71%),涉及肝脏不良反应药物排名前3位的是心血管系统药物(38例,32.20%)、中药(32例,27.12%)及内分泌系统药物(13例,11.02%)。结论女性更易发生药物性肝脏不良反应,最多见引发肝脏不良反应的药物为心血管系统药物。提示医疗机构应加强医务人员培训,提高医务人员对药物致肝脏相关不良反应的认识,做到积极预防,尽早识别,及时治疗。Objective To investigate the incidence and clinical characteristics of drug-induced liver injury and provide reference for medication. Methods The medical records of drug induced liver injury collected from the hospital information management system between January 1, 2016 and December 31, 2019 were retrospectively analyzed. The basic information, biochemical indexes, clinical classification, grades of injuries, drugs involved, onset time, outcomes and therapeutic drugs were recorded. Results Fifty males and sixty-five females with a mean age of(57.98±16.64) years were enrolled in this study. Drug induced liver injury mostly occurred within 3 months of medication(n=74, 62.71%). The top three drugs were cardiovascular agents(n=38, 32.20%), traditional Chinese medicine(n=32, 27.12%) and endocrine drugs(n=13, 11.02%). Conclusion This study has found that females are more vulnerable to liver injury, and that cardiovascular drugs are most likely to lead to liver injury. Medical institutions should strengthen medical staff’s training,advance their understanding of drug induced liver injury, and ensure active prevention, early identification and quick treatment for patients.

关 键 词：肝脏 药品不良反应 合理用药 

分 类 号：R994.11[医药卫生—毒理学]