乙酰半胱氨酸胶囊联合福多司坦片致多形红斑型药疹1例分析  

One case of erythema multiforme drug eruption induced by acetylcysteine capsule combined with fudosteine tablets

作　　者：王新[1] 张捷 张明[1] 张楠[1] 艾超 WANG Xin;ZHANG Jie;ZHANG Ming;ZHANG Nan;AI Chao(Department of Pharmacy,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing 102218,China)

机构地区：[1]清华大学附属北京清华长庚医院药学部,清华大学临床医学院,北京102218

出　　处：《中国药物警戒》2022年第2期217-218,223,共3页Chinese Journal of Pharmacovigilance

摘　　要：目的探讨乙酰半胱氨酸胶囊联合福多司坦片致多形红斑型药疹的可能机制。方法分析2020年2月发生的1例由口服乙酰半胱氨酸胶囊联合福多司坦片致多形红斑型药疹的病例资料并进行文献分析。结果患者在服用乙酰半胱氨酸胶囊和福多司坦片3 d后,足部出现水疱,随后皮肤溃破,并出现表皮剥脱,后手部出现相同症状,考虑为药物引起的多形红斑型药疹,停用乙酰半胱氨酸胶囊和福多司坦片后,患者皮肤症状逐渐好转。结论乙酰半胱氨酸胶囊与福多司坦片联合应用可能会引起多型红斑型药疹,在临床应用过程中应加强对药品不良反应的关注。Objective To explore the possible mechanism by which acetylcysteine capsules combined with fordostetin tablets cause erythema multiforme drug eruption. Methods One case of erythema multiforme drug eruption caused by oral acetylcysteine capsules combined with fordosteine tablets in February 2020 and rdlared Literature were analyzed. Results Three days after taking acetylcysteine capsules and fudosteine tablets, the patient had blisters on feet, followed by skin rupture and epidermal peeling. The same symptoms were then observed in hands, which was believed to be erythema multiform drug eruption caused by drugs. After the discontinuation of acetylcysteine capsules and fudosteine tablets, the patient’s skin symptoms gradually improved. Conclusion The combined application of acetylcysteine capsules and fudosteine tablets may cause erythema multiform drug eruption, so clinicians should be alert to related adverse drug reactions.

关 键 词：乙酰半胱氨酸胶囊 福多司坦片 多形红斑型药疹 用药安全 药品不良反应 

分 类 号：R969.3[医药卫生—药理学] R994.11[医药卫生—药学]