吉林地区帕金森病(颤证)中医证候及用药规律横断面研究  

Cross sectional study on the TCM syndromes and medication laws of Parkinson’s disease(fi brillation syndrome)in Jilin Province

作　　者：马洪歌 孙丹 徐靖婷 吴大龙[1] MA Hongge;SUN Dan;XU Jingting;WU Dalong(Department of Encephalopathy,Affiliated Hospital of Changchun University of Chinese Medicine,Changchun 130021,China;Changchun University of Chinese Medicine,Changchun 130021,China)

机构地区：[1]长春中医药大学附属医院脑病科,长春130021 [2]长春中医药大学,长春130021

出　　处：《吉林中医药》2022年第3期315-319,共5页Jilin Journal of Chinese Medicine

基　　金：2020年吉林省中医药科技项目(2020066)。

摘　　要：目的对吉林地区80例帕金森病(PD)患者的中医证候要素及用药进行分析,为深入剖析帕金森病用药思路、药物选择及中医证候要素表的制定等提供依据。方法采用临床流行病学方法及相关统计学方法对帕金森病患者中医证候要素及用药规律进行分析,总结并分析中医证候在帕金森病(颤证)中不同分期中的分布规律及用药规律。结果通过对80例患者证型及方剂分析得出,出现频次较多的证型为风阳内动证24例(30.00%)、痰热风动证19例(23.75%);出现频次较多的方剂为天麻钩藤饮20例(25.00%)、大柴胡汤18例(22.50%),且各期所占比例较稳定。9种证候要素共出现144频次,其中内风(36.81%)所占比例最多,其次为内热(20.83%)、痰湿(14.58%)、阴虚(11.81%)。结论风阳内动证、痰热风动证是帕金森病的主要中医证型,天麻钩藤饮、大柴胡汤是帕金森病应用较多的方剂,内风、内热、痰湿、阴虚是PD的主要证候要素,PD与肝、脾、肾密切相关,但由于本次研究观察的病例有限,仍需更多样本来观察验证。Objective To analyze the TCM syndrome elements and medication of the 80 Parkinson’s disease(PD)patients in Jilin Province,and to provide a basis for the in-depth analysis of Parkinson’s disease medication ideas,drug selection and formulation of TCM syndrome elements table.Methods Clinical epidemiological methods and related statistical methods were used to analyze the TCM syndrome elements and medication patterns in patients with Parkinson’s disease,and to summarize and analyze the distribution laws of TCM syndromes in diff erent stages of Parkinson’s disease(with the fibrillation syndrome)and varying medication patterns.Results By analyzing the syndrome types and prescriptions of the 80 patients,it was concluded that the most frequent syndrome patterns were the syndrome of internal stirring of wind yang in 24 cases(30.00%)and the syndrome of wind stirring due to phlegm-heat in 19 cases(23.75%,while the most frequent prescriptions were Tianma Gouteng Decoction in 20 cases(25.00%)and Dachaihu Decoction in 18 cases(22.50%),and their proportions in each stage were relatively stable.There were 144 frequencies of the 9 syndrome elements,of which internal wind(36.81%)accounted for the largest proportion,followed by internal heat(20.83%),phlegm-dampness(14.58%),and yin deficiency(11.81%).Conclusion The syndrome of internal stirring of wind yang and the syndrome of wind stirring due to phlegm-heat are the two main TCM syndromes of Parkinson’s disease,while Tianma Gouteng Decoction and Dachaihu Decoction are the most commonly used prescriptions for it.Internal wind,internal heat,phlegm dampness and yin defi ciency are the main syndrome elements of PD and PD is closely related to the liver,spleen and kidney.However,due to the limited cases observed in this study,more samples are still needed for its further observation and verifi cation.

关 键 词：帕金森病 证候要素 方剂 H-Y分期 

分 类 号：R277.7[医药卫生—中医学]