Effect of hydrophilic or hydrophobic interactions on the self-assembly behavior and micro-morphology of a collagen mimetic peptide  

作　　者：Xiaomin Luo Qianqian Huo Xinhua Liu Chi Zheng Ying Liu 

机构地区：[1]College of Bioresources Chemical and Materials Engineering,Shaanxi University of Science&Technology,Wei Yang District,Xi’an 710021,Shaanxi,China [2]National Demonstration Center for Experimental Light Chemistry Engineering Education,Shaanxi University of Science&Technology,Weiyang District,Xi’an 710021,Shaanxi,China [3]Institute of Biomass&Functional Materials,Shaanxi University of Science&Technology,Weiyang District,Xi’an 710021,Shaanxi,China

出　　处：《Journal of Leather Science and Engineering》2021年第1期121-130,共10页皮革科学与工程（英文）

基　　金：This work was financially supported by the National Natural Science Foundation of China(21808133);Scientific Research Foundation for Young Scholars of Shaanxi University of Science&Technology(contract grant number 2017BT-32);Xianyang Science and Technology Project(Y20190138);Shaanxi Province Key R&D Program(2018ZDXM-SF-091).

摘　　要：Peptide self-assembles with bionic properties have been widely utilized for bioactive drugs and biomedical materials.Collagen mimetic peptide(CMP)gains more attention due to its unique advantages in biosecurity and function.Unfortunately,the self-assembly mechanism of CMP,particularly the effect of intermolecular forces on its self-assembly behavior and morphology,is still unrecognized.Herein,the hydrophilic glycidol(GCD)and hydrophobic Y-glycidyl ether oxypropyl trimethoxysilane(GLH)were grafted onto the side chains of CMP through the ring-opening reaction(GCD/CMP,GLH/CMP).Subsequently,the effects of hydrophilic and hydrophobic interactions on the self-assembly behavior and morphology of CMP were further studied.The results substantiated that the GCD/CMP and GLH/CMP self-assembly followed“nucleation-growth”mechanism,and the supererogatory hydrophilic and hydrophobic groups prolonged the nucleation and growth time of CMP self-assembly.Noted that the hydrophilic interaction had stronger driving effects than hydrophobic interaction on the self-assembly of CMP.The GCD/CMP and GLH/CMP self-assembles exhibited fibrous 3D network and microsphere morphology,respectively.Furthermore,the GLH/CMP self-assembles had better resistance to degradation.Consequently,the microtopography and degradation properties of CMP self-assembles could be controlled by the hydrophilic and hydrophobic interactions between CMP,which would further provide a way for subsequent purposeful design of biomedical materials.

关 键 词：Collagen mimetic peptide Hydrophilic interaction and hydrophobic interaction SELF-ASSEMBLY MORPHOLOGY 

分 类 号：O15[理学—数学]