控制性再灌注在缺血再灌注损伤中的应用进展  

Research progress of controlled reperfusion in reducing ischemia-reperfusion injury

作　　者：冉秋林 刘志刚[1] RAN Qiulin;LIU Zhigang(Department of Cardiovascular Surgery,TEDA International Cardiovascular Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300457,China)

机构地区：[1]中国医学科学院北京协和医学院泰达国际心血管病医院心外科,天津300457

出　　处：《老年医学研究》2022年第1期38-41,共4页Geriatrics Research

摘　　要：目前再灌注治疗策略已被广泛应用于心肌梗死和缺血性卒中等缺血性疾病的临床治疗中,但是大量的实验和临床证据表明,再灌注治疗会对缺血组织器官造成额外的再灌注损伤。控制性再灌注可在一定程度上减轻缺血再灌注损伤,为缺血性疾病的治疗提供了新思路。目前,该方向的研究主要集中于缺氧后处理、控制性高氧再灌注、流量控制再灌注、压力控制再灌注、控制性酸化再灌注和离子控制再灌注等方面。Currently,reperfusion therapy strategy has been widely used in the clinical treatment of ischemic diseas⁃es such as myocardial infarction and ischemic stroke,but a large number of experiments and clinical evidence show that re⁃perfusion therapy will cause additional reperfusion injury to ischemic tissues and organs.Controlled reperfusion can reduce ischemia-reperfusion injury to some extent,which provides a new idea for the treatment of ischemic diseases.At present,the research in this direction is mainly focused on hypoxia postconditioning,controlled hyperoxia reperfusion,flow control reperfusion,pressure control reperfusion,controlled acidotic reperfusion and controlled ionic reperfusion and so on.

关 键 词：缺血性疾病 控制性再灌注 再灌注损伤 血运重建 心肌梗死 缺血性卒中 

分 类 号：R331.3[医药卫生—人体生理学]