双嘧达莫、阿司匹林联合丙种球蛋白对川崎病患儿血清TNFα/PCT和白细胞介素水平的影响  

Effects of Dipyridamole,Aspirin,and Gamma Globulin on Serum TNFα/PCT and Interleukin Levels in Children with Kawasaki Disease

作　　者：浮纪玲 郭宏敏 王民杰 FU Ji-ling;GUO Hong-min;WANG Min-jie(Department of Pediatrics,Xinxiang First People's Hospital,Xinxiang 453000,Henan Province,China)

机构地区：[1]新乡市第一人民医院儿科,河南新乡453000

出　　处：《罕少疾病杂志》2022年第4期5-7,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的本研究分析双嘧达莫、阿司匹林联合丙种球蛋白对川崎病(KD)患儿血清TNFα/PCT和白细胞介素水平的影响,为临床治疗提供参考。方法以本院2017年1月至2018年12月期间收治的川崎病患儿为研究对象。72例患者中观察组(n=36)接受双嘧达莫、阿司匹林联合丙种球蛋白治疗,对照组(n=36)接受阿司匹林联合丙种球蛋白治疗。分析患者治疗的临床效果,并检测治疗前后患儿血清TNFα/PCT和白细胞介素水平的变化。结果观察组的总有效率明显高于对照组(P<0.05),发热缓解时间、四肢肿胀缓解时间、躯干红斑缓解时间、粘膜充血缓解时间均明显短于对照组(P<0.05)。两组患者经治疗后血清中TNFα、PCT及白细胞介素IL6、IL8、IL10水平均明显降低(P<0.05),且观察组的上述指标降低较对照组更明显(P<0.05)。结论双嘧达莫、阿司匹林联合丙种球蛋白能有效治疗川崎病患儿,且可显著降低血清TNFα/PCT和白细胞介素水平。Objective To study the effects of dipyridamole,aspirin and gamma globulin on serum TNFα/PCT and interleukin levels in children with Kawasaki disease.Methods The children with Kawasaki disease admitted to our hospital from January 2017 to December 2018 were studied.The observation group(n=36)was treated with dipyridamole,aspirin and gamma globulin.The control group(n=36)received aspirin combined with gamma globulin treatment.To analyze the clinical effect of patients'treatment.The serum levels of TNFα/PCT and interleukin were measured before and after treatment.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).The fever alleviation time,limb swelling alleviation time,trunk erythema alleviation time and mucosal congestion alleviation time of the observation group were significantly shorter than those of the control group(P<0.05).After treatment,serum levels of TNFα,PCT,IL-6,IL-8 and IL-10 in both groups were significantly decreased(P<0.05).The above indexes in the observation group were lower than those in the control group(P<0.05).Conclusion Dipyridamol,aspirin and gamma globulin can effectively treat Kawasaki disease,and can significantly reduce serum TNFα/PCT and interleukin levels.

关 键 词：双嘧达莫 阿司匹林 丙种球蛋白 川崎病 白细胞介素 肿瘤坏死因子 降钙素 

分 类 号：R725.9[医药卫生—儿科] R543[医药卫生—临床医学]