脉冲电磁场对成骨细胞的作用机制  

Mechanisms of effect of pulsed electromagnetic field on osteoblast

作　　者：邓叶龙 赵军[2] 孔令俊[3] 刘朝辉[3] 高文婷 李兴国[3] 杨德龙 DENG Ye-long;ZHAO Jun;KONG Ling-jun;LIU Zhao-hui;GAO Wen-ting;LI Xing-guo;YANG De-long(Clinical College of Traditional Chinese Medicine, Gansu University of Traditional Chinese Medicine,Lanzhou 730030, China;Trauma Center, Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050, China;Department of Osteoporosis, Gansu Provincial Hospital ofTraditional Chinese Medicine, Lanzhou 730050, China)

机构地区：[1]甘肃中医药大学中医临床学院,兰州730030 [2]甘肃省中医院创伤中心,兰州730050 [3]甘肃省中医院骨质疏松科,兰州730050

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2021年第6期709-714,共6页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：甘肃省中医药管理局项目(GZKP-2020-19);研究生创新基金项目(2021CX16)。

摘　　要：脉冲电磁场(pulsed electromagnetic fields,PEMFs)应用于骨质疏松症(osteoporosis,OP)的预防和治疗一直是人们感兴趣的领域。成骨细胞(osteoblast,OB)是骨形成的主要功能细胞,负责骨基质的合成、分泌和矿化,在骨重建过程中发挥重要作用。虽然PEMFs能影响OB的活性,使细胞增殖或分化,进而对OP产生积极作用,但其精确生物效应和潜在作用机制仍不清楚。本文从基础研究着手,将PEMFs对OB潜在作用机制进行综述,旨在为骨组织工程研究和临床治疗OP提供参考。The application of pulsed electromagnetic fields(PEMFs)in the prevention and treatment of osteoporosis(OP)has always been an interesting field.Osteoblast(OB)is the main functional cell of bone formation and responsible for the synthesis and secretion of bone matrix and mineralization.OB also plays an important role in the bone reconstruction.Although PEMFs can influence the activity of OB,leading to cell proliferation or differentiation,and have positive effects on the OP,the precise biological effect and potential mechanism is still unclear.This article starts from basic research and reviewed the potential mechanism of PEMFs on OB,aiming to provide references for bone tissue engineering research and clinical treatment of OP.

关 键 词：脉冲电磁场 成骨细胞 骨质疏松症 作用机制 

分 类 号：R681[医药卫生—骨科学] R454.1[医药卫生—外科学]