恩拉霉素提取工艺研究  

Extraction Technology of Enramycin

作　　者：闵江 娄燕 刘正光 赵才兵 张翠芬 高鹏 王丹丹 陈森 梁景乐 MIN Jiang;LOU Yan;LIU Zheng-guang;ZHAO Cai-bing;ZHANG Cui-fen;GAO Peng;WANG Dan-dan;CHEN Sen;LIANG Jing-le(Shandong Shengli Bioengineering Co, LTD, Jining, Shandong, 272000,China;China Animal Husbandry Industry Co., Ltd, Beijing 100095,China)

机构地区：[1]山东胜利生物工程有限公司,山东济宁272000 [2]中牧实业股份有限公司,北京100095

出　　处：《中国兽药杂志》2022年第2期42-45,共4页Chinese Journal of Veterinary Drug

摘　　要：为优化恩拉霉素提取工艺,以70%甲醇溶液为提取剂,提取恩拉霉素,经过浓缩、脱色、结晶、重结晶,制备高含量恩拉霉素产品。得到最佳提取工艺条件是:浸提pH3.5~4.0,浸提温度30℃,三次浸提时间1 h,一次浸提料液比1∶7,二次浸提料液比1∶3,三次浸提料液比1∶3,活性炭用量是浓缩液体积的1.0%~1.5%,粗精粉重结晶得到纯品,含量97%。To optimize extraction technology of Enramycin,70%methanol solution was used to extract Enramycin,and then was concentrated,decolorized,crystallized,recrystallized.The active pharmaceutical ingredient(API)was produced.The optimized extraction technological conditions were pH 3.5~4.0,temperature 30℃,extraction time1h,three extraction process ed with material-liquid ratios 1∶7,1∶3,1∶3,1.0%~1.5%ratio of activated carbon/concentrated solution,recrystallized once.The product of Enramycin was 97%.

关 键 词：恩拉霉素 提取工艺 甲醇 

分 类 号：S859.79[农业科学—临床兽医学]