基于红外热成像技术探讨隔药灸治疗膝骨关节炎的疗效观察及对血清CS846、S100A8/A9及炎症因子的影响  

Infrared Thermography-based Investigation of the Efficacy Observation of Herbs-partition Moxibusition for Knee Osteoarthritis and Its Effects on Serum CS846,S100A8/A9 and Inflammatory Factors

作　　者：姜赞英 范惠霞 樊志丽 JIANG Zanying;FAN Huixia;FAN Zhili(Zhejiang University of Traditional Chinese Medicine Huzhou Hospital of Traditional Chinese Medicine,Huzhou 313000,China)

机构地区：[1]浙江中医药大学附属湖州中医院,湖州313000

出　　处：《上海针灸杂志》2022年第3期258-263,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：浙江省中医药科技计划项目(2021ZA132)。

摘　　要：目的基于红外热成像技术探讨隔药灸治疗膝骨关节炎的临床疗效及对患者血清硫酸软骨素846(CS846)、钙卫蛋白(S100A8/A9)、炎症因子和Lysholm膝关节评分及肢体平衡的影响。方法将120例肾虚寒凝型膝骨关节炎患者随机分为对照组和研究组,每组60例。对照组予以常规西药治疗,研究组在对照组治疗基础上加用隔药隔姜温通灸法治疗。观察两组治疗前后体表观测点的红外热成像测定值、血清CS846、血清S100A8/A9、血清炎症因子、Lysholm膝关节评分、肢体平衡,以及两组患者的CS846、S100A8/A9、炎症因子与Lysholm膝关节评分的相关性,并比较两组临床疗效。结果治疗后两组体表观察点温度均较治疗前改善(P<0.05),且研究组患者体表观察点温度低于对照组(P<0.05)。治疗后两组血清CS846、S100A8/A9、炎症因子水平均较治疗前有明显改善(P<0.05),且研究组优于对照组(P<0.05)。治疗后两组Lysholm膝关节评分、前后轴稳定指数与左右轴稳定指数较治疗前有明显改善(P<0.05),且研究组优于对照组(P<0.05)。相关性分析显示CS846、S100A8/A9、白介素-6、白介素-10、肿瘤坏死因子-α与Lysholm膝关节评分呈负相关(P<0.05)。治疗后联合组总有效率(93.3%)显著优于对照组(80.0%),差异有统计学意义(P<0.05)。结论隔药隔姜温通灸法治疗肾虚寒凝证膝骨关节炎的临床疗效显著,可有效控制CS846、S100A8/A9及炎症因子,改善疾病症状,提高膝关节功能,促进肢体平衡能力的恢复。Objective To observe the clinical efficacy of herbs-partition moxibusition in treating knee osteoarthritis and its effects on serum CS846,S100A8/A9 and inflammatory factors,and the Lysholm knee score and limb balance.Method One hundred and twenty patients with knee osteoarthritis of kidney deficiency and cold coagulation syndrome were randomized to control and study groups,with 60 cases in each group.The control group received conventional treatment with western medicine and the study group,Chinese herbal medicine and ginger juice mixture-partition moxibusition for warming and unblocking in addition.Infrared thermographic inspection value on the body surface observation point,serum CS846,S100A8/A9 and inflammatory factors,and the Lysholm knee score and limb balance were observed in the two groups before and after treatment.The correlation between CS846,S100A8/A9,inflammatory factors and Lysholm knee score in two groups were observed.The clinical therapeutic effects were also compared between the two groups.Result After treatment,temperature on the body surface observation point decreased in both groups compared with before(P<0.05)and was lower in the study group than in the control group(P<0.05).After treatment,serum CS846,S100A8/A9 and inflammatory factor levels improved significantly in both groups compared with before(P<0.05)and were better in the study group than in the control group(P<0.05).After treatment,the Lysholm knee score,the anterio-posterior axis stability index and the left-right axis stability index improved significantly in the two groups compared with before(P<0.05)and were better in the study group than in the control group(P<0.05).Correlation analysis showed that CS846,S100A8/A9,interleukin-6,interlukin-10 or tumor necrosis factor-αand the Lysholm knee score had a negative correlation(P<0.05).After treatment,the total efficacy rate was significantly higher in the combination group(93%)than in the control group(80.0%)(P<0.05).Conclusion Medicine-ginger mixture-partition moxibusition for warmin

关 键 词：药饼灸疗法 肾虚寒凝 骨关节炎 膝 红外热成像技术 Lysholm膝关节评分 

分 类 号：R246.2[医药卫生—针灸推拿学]