中国大陆淡水鱼华支睾吸虫感染率的meta分析  

Prevalence of Clonorchis sinensis infections in freshwater fish in China's Mainland:A meta-analysis

作　　者：戴思敏 余晴 马晓疆[1] 王真瑜[1] 张耀光[1] 朱民[1] 张宸罡 朱倩[1] 江莉[1] 靳艳军[1] 潘浩[1] 吴寰宇[1] DAI Si-min;YU Qing;MA Xiao-jiang;WANG Zhen-yu;ZHANG Yao-guang;ZHU Min;ZHANG Chen-gang;ZHU Qian;JIANG Li;JIN Yan-jun;PAN Hao;WU Huan-yu(Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200025,China)

机构地区：[1]上海市疾病预防控制中心,上海200025

出　　处：《中国血吸虫病防治杂志》2022年第1期16-27,35,共13页Chinese Journal of Schistosomiasis Control

基　　金：上海市第五轮公共卫生体系建设三年行动计划重点学科项目(GWV-10.1-XK13)。

摘　　要：目的了解中国大陆淡水鱼华支睾吸虫感染实际水平,为华支睾吸虫病防控和淡水鱼卫生检测提供科学依据。方法以万方数据资源系统、中国期刊全文数据库(CNKI)、PubMed、Web of Science、Embase、Cochrane Library等中英文数据库为数据源,检索2010年1月1日至2020年12月31日发表的有关中国大陆淡水鱼华支睾吸虫感染状况的文献,根据纳入和排除标准筛选文献,并进行文献质量评价。利用Stata 15.0软件计算淡水鱼华支睾吸虫合并感染率及其95%可信区间(confidential interval,CI),并对不同地区、不同采样季节、不同来源淡水鱼华支睾吸虫合并感染率进行亚组分析。此外,对所纳入研究的敏感性及发表偏倚进行分析。结果共纳入文献40篇,其中中文文献37篇、英文文献3篇,高质量文献10篇、中等质量文献27篇、低质量文献3篇。40项研究共纳入53种、37 959条淡水鱼,其中39种(占73.58%)淡水鱼感染华支睾吸虫。meta分析结果显示,淡水鱼华支睾吸虫感染率为23.5%[95%CI:(0.19,0.28)];亚组分析结果表明,东北地区淡水鱼华支睾吸虫感染率达35.7%[95%CI:(0.22,0.50)],高于华中地区[25.9%,95%CI:(0.04,0.48)]和华南地区[20.6%,95%CI:(0.09,0.32)];春季采样的淡水鱼样本华支睾吸虫感染率为44.1%[95%CI:(0.35,0.53)],高于秋季[6.7%,95%CI:(0.05,0.08)]和夏季[3.3%,95%CI:(-0.01,0.07)];来源于自然水体的淡水鱼华支睾吸虫感染率为25.2%[95%CI:(0.17,0.33)],高于来源于零售环节[22.2%,95%CI:(0.17,0.28)]和养殖环节[12.3%,95%CI:(0.03,0.22)]的淡水鱼。所纳入文献敏感性较低,存在发表偏倚。结论中国大陆淡水鱼华支睾吸虫感染率较高,华支睾吸虫病防控任务依然艰巨,需要加强健康教育、诊断技术开发和食品安全监管等方面工作。Objective To understand the real prevalence of Clonorchis sinensis infections in the freshwater fish in China's Mainland, so as to provide insights into clonorchiasis control and detection of freshwater fish. Methods All literatures reporting the prevalence of C. sinensis infections in the freshwater fish, the second intermediate host of the parasite, were jointly retrieved in Chinese and English electronic databases from January 1, 2010 to December 31, 2020, including Wanfang Data, CNKI, PubMed,Web of Science, Embase and Cochrane Library. All studies were screened based on inclusion and exclusion criteria, and the quality of all enrolled literatures was evaluated. The pooled prevalence of C. sinensis infections in freshwater fish and its 95% confidence interval(CI) were estimated using the software Stata version 15.0, and subgroup analyses were performed to investigate the region-, season-and sample source-specific pooled prevalence of C. sinensis infections in freshwater fish. In addition, the sensitivity and publication bias of all included studies were analyzed. Results A total of 40 eligible literatures were included in this study, including 37 Chinese literatures and 3 English literatures, and there were 10 high-quality literatures, 27 moderatequality literatures and 3 low-quality literatures. A total of 53 species containing 37 959 freshwater fish were reported in these 40 studies, and 73.58%(39/53) of freshwater fish species were identified with C. sinensis infections. Meta-analysis showed 23.5% [95% CI:(0.19, 0.28)] pooled prevalence of C. sinensis infections in freshwater fish in China's Mainland, and subgroup analyses higher prevalence of C. sinensis infections in freshwater fish in northeastern China [35.7%, 95% CI:(0.22, 0.50)] than in central[25.9%, 95% CI:(0.04, 0.48)] and southern China [20.6%, 95% CI:(0.09, 0.32)], higher prevalence of C. sinensis infections in freshwater fish sampled in spring [44.1%, 95% CI:(0.35, 0.53)] than in autumn [6.7%, 95% CI:(0.05, 0.08)] and summer [3.3%,95% CI:(-0.01,

关 键 词：华支睾吸虫 淡水鱼 第二中间宿主 META分析 

分 类 号：R383.22[医药卫生—医学寄生虫学]