局部枸橼酸抗凝在单重血浆置换治疗中的应用研究进展  

Recent advances in simple plasma exchange therapy with regional citrate anticoagulation

作　　者：李晓冉 马元吉[1] 白浪[1] 唐红[1] Li Xiaoran;Ma Yuanji;Bai Lang;Tang Hong(Center of Infectious Diseases,West China Hospital of Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院感染性疾病中心,成都610041

出　　处：《中华临床感染病杂志》2021年第6期475-480,共6页Chinese Journal of Clinical Infectious Diseases

基　　金：国家重大科技专项(2018ZX10715-003);四川大学华西医院学科卓越发展1·3·5工程项目(2019HXFH072)。

摘　　要：血浆置换治疗通过清除致病因子和调节免疫系统功能等作用治疗多器官系统重症免疫病和重症肝病。局部枸橼酸抗凝不影响体内凝血功能,不增加出血风险,是血浆置换治疗的可选抗凝方式之一。本文对国内外的单重血浆置换治疗实施局部枸橼酸抗凝的研究进行综述,为临床医师开展该类治疗提供参考。Plasma exchange therapy is applied for treatment of severe immune diseases of multiple organ systems and severe liver diseases by removing pathogenic factors and regulating immune function.Regional citrate anticoagulation has no effect on systemic coagulation function and does not increase bleeding risk,and it is one of the optional anticoagulation methods for plasma exchange therapy.This article reviews recent literature on simple plasma exchange therapy with regional citrate anticoagulation to provide a reference for clinical application of this therapy.

关 键 词：血浆置换 单重血浆置换 局部枸橼酸抗凝 肝衰竭 

分 类 号：R969[医药卫生—药理学]