基于CCTA冠状动脉周围脂肪衰减指数应用于高危可疑冠心病评估的可行性研究  

Measurement of Fat Attenuation Index Based on Coronary CT Angiography for High-risk Suspected Coronary Heart Disease Patients:A Feasibility Study

作　　者：唐异蓓 张卡雄 赵磊[3] 刘挨师[3] 王利东 TANG Yibei;ZHANG Kaxiong;ZHAO Lei(Graduate School,Inner Mongolia Medical University,Inner Mongolia Autonomous Region 010059,China)

机构地区：[1]内蒙古医科大学研究生学院,呼和浩特010059 [2]内蒙古医科大学第一临床学院,呼和浩特010059 [3]内蒙古医科大学附属医院影像诊断科,呼和浩特010021 [4]内蒙古国际蒙医医院/内蒙古医科大学附属蒙医医院影像诊断科,呼和浩特010013

出　　处：《医学研究杂志》2022年第2期47-51,共5页Journal of Medical Research

基　　金：内蒙古自治区关键技术攻关项目(2019GG070);内蒙古医科大学科技百万工程联合项目[YKD2020KJBW(LH)029];内蒙古医科大学第一临床医学院启蒙计划项目(FYQMJH2020005)。

摘　　要：目的通过测量狭窄斑块冠状动脉周围(以下简称冠周)FAI,并与狭窄程度、斑块特征与FFR_(CT)进行对比分析,旨在评价FAI能否为冠状动脉性心脏病(CAD)提供额外诊疗证据。方法回顾性分析36例具有高危风险可疑CAD患者,并接受CCTA检查与FAI、FFR_(CT)进一步分析。对梗阻性狭窄与正常管腔冠周FAI、FFR异常与正常冠周FAI、不同冠状动脉斑块类型冠周FAI进行比较,并对不同冠状动脉狭窄程度冠周FAI与其影响因素进行相关分析。结果实际纳入36例患者,共计评价血管108支。梗阻性狭窄管腔与正常管腔冠周FAI比较,差异有统计学意义(P<0.05);梗阻性冠状动脉周围FAI与FFR_(CT)比较,差异有统计学意义(P<0.05);不同冠状动脉狭窄程度与冠周FAI呈中度正相关(r=0.508,P<0.05);无斑块冠周FAI与有斑块冠周FAI比较,差异有统计学意义(P<0.05)。冠周FAI、FFR_(CT)、冠状动脉狭窄程度与斑块类型存在一致性(P<0.05)。结论冠周FAI可间接提供多项关联指标,是可解释管腔狭窄所致血流动力学改变的重要途径。Objective To evaluate whether FAI can provide additional diagnosis and treatment evidence for CAD by measuring FAI,stenosis,plaque characteristics and FFR_(CT).Methods Totally 36 patients with suspected CAD with high-risk were analyzed retrospectively,and were further analyzed by CCTA,FAI and FFR_(CT).Obstructive stenosis with normal lumen FAI,abnormal FFR with normal FAI,and FAI of different types of coronary plaque were compared,and the correlation between different degrees of coronary stenosis and their influencing factors were analyzed.Results Totally 36 patients were included,and a total of 108 vessels were evaluated.There was significant difference in FAI between obstructive narrow lumen and normal lumen(P<0.05).There was significant difference between FAI and FFR_(CT) around obstructive coronary artery(P<0.05).There was a moderate positive correlation between different degrees of coronary artery stenosis and FAI(r=0.508,P<0.05).There was significant difference between plaque free and plaque free coronal FAI(P<0.05).The degree of coronary artery stenosis was consistent with the type of plaque(P<0.05).Conclusion FAI can indirectly provide a number of correlation indexes,which is an important way to explain the hemodynamic changes caused by lumen stenosis.

关 键 词：体层摄影术 脂肪衰减指数 动脉粥样硬化 血流储备分数 

分 类 号：R816.2[医药卫生—放射医学]