血清胱抑素C与2型糖尿病早期血管病变的相关性研究  

Relationship between Serum Cystatin C Level and Pre-atherosclerosis in Type 2 Diabetes Mellitus Patients

作　　者：王俊[1] 尤巧英[1] 黄迪华[1] 诸葛福媛[1] WANG Jun;YOU Qiaoying;HUANG Dihua(Department of Endocrinology and Metabolism,Shaoxing People′s Hospital,Zhejiang 312000,China)

机构地区：[1]绍兴市人民医院内分泌代谢科,312000

出　　处：《医学研究杂志》2022年第2期119-123,共5页Journal of Medical Research

基　　金：浙江省绍兴市公益性技术应用研究计划项目(2018C30105)。

摘　　要：目的探索血清胱抑素C(Cys C)水平与2型糖尿病(type 2 diabetes mellitus,T2DM)动脉粥样硬化早期的关系。方法本研究为横断面研究,选取绍兴市人民医院2018年12月~2019年12月收治的T2DM患者120例。反应性充血指数(reactive hyperemia index,RHI)>1.67且颈动脉内膜中层厚度(intima-media thickness,IMT)<1.2mm者为A组(40例),RHI≤1.67且IMT<1.2mm者为B组(40例),RHI≤1.67且IMT≥1.2mm者为C组(40例)。对3组患者行常规血生化检查,体格检查及测定血清Cys C水平,分析其与动脉粥样硬化早期的关系。结果3组中Cys C与RHI有相关性(r分别为-0.317、-0.385、-0.516,P<0.05)。Logistic回归分析显示,尿酸(UA)(标准化β=0.239)、Cys C(标准化β=-0.676)均与RHI独立相关(P均<0.05)。血清Cys C(标准化β=-0.676,P<0.001)升高是动脉粥样硬化的相关因素。结论血清Cys C水平可能与T2DM动脉粥样硬化早期的发生、发展相关。Objective To investigate the relationship between serum cystatin C(Cys C)levels and pre-atherosclerosis in type 2 diabetes mellitus(T2DM)patients.Methods A cross-sectional study was carried out between December 2018 to December 2019,and T2DM patients which selected as subjects were 120 cases.Patients with reactive hyperemia index(RHI)>1.67 with intima-media thickness<1.2mm were in group A(40 cases),those with RHI≤1.67 and intima-media thickness<1.2mm were in group B(40 ca-ses),those with RHI≤1.67 and intima-media thickness≥1.2mm were in group C(40 cases).Physical and blood biochemical exami-nation were performed in all groups.Serum Cys C was measured and its relationship with pre-atherosclerosis was analyzed.Results There was a statistically significant correlation between serum Cys C and RHI in all groups(r were-0.317,-0.385,-0.516;P<0.05).Logistics regression analysis showed that UA(Standardized betavalue=0.239)and Cys C(Standardized betavalue=-0.676)were independently correlated with RHI(P<0.05).The elevation of serum Cys C(Standardized betavalue=-0.676,P=0.000)was correla-tive factor for atherosclerosis.Conclusion The serum Cys C may be related to the occurrence and development of T2DM pre-atheroscle-rosis in T2DM patients.

关 键 词：2 型糖尿病 半胱氨酸蛋白酶抑制剂 C 反应性充血指数 动脉粥样硬化 

分 类 号：R589[医药卫生—内分泌]