Predicting flows through microfluidic circuits with fluid walls  

作　　者：Cyril Deroy Nicholas Stovall-Kurtz Federico Nebuloni Cristian Soitu Peter R.Cook Edmond J.Walsh 

机构地区：[1]Department of Engineering Science,Osney Thermo-Fluids Laboratory,University of Oxford,Oxford OX20ES,UK [2]Sir William Dunn School of Pathology,University of Oxford,Oxford OX13RE,UK [3]Cold Spring Harbor Laboratory,Cold Spring Harbor,NY,USA

出　　处：《Microsystems & Nanoengineering》2021年第6期119-127,共9页微系统与纳米工程（英文）

基　　金：This work was supported by iotaSciences Ltd.(who provided financial support for C.D.,F.N.,and C.S.);the William H.G.FitzGerald Scholarship(N.S.‐K.);the Impact Acceleration Account of the Biotechnology and Biological Sciences Research Council(P.R.C.and E.J.W.);awards from the Medical Research Council under the Confidence in Concept scheme(MC_PC_15029 to P.R.C.and E.J.W).

摘　　要：The aqueous phase in traditional microfluidics is usually confined by solid walls;flows through such systems are often predicted accurately.As solid walls limit access,open systems are being developed in which the aqueous phase is partly bounded by fluid walls(interfaces with air or immiscible liquids).Such fluid walls morph during flow due to pressure gradients,so predicting flow fields remains challenging.We recently developed a version of open microfluidics suitable for live-cell biology in which the aqueous phase is confined by an interface with an immiscible and bioinert fluorocarbon(FC40).Here,we find that common medium additives(fetal bovine serum,serum replacement)induce elastic no-slip boundaries at this interface and develop a semi-analytical model to predict flow fields.We experimentally validate the model’s accuracy for single conduits and fractal vascular trees and demonstrate how flow fields and shear stresses can be controlled to suit individual applications in cell biology.

关 键 词：walls FLOWS FLOW 

分 类 号：O35[理学—流体力学]