血清胱抑素C、超敏C反应蛋白预测老年心律失常心力衰竭病人预后的效能研究  

Effects of serum cystatin C and high-sensitivity C-reactive protein in predicting prognosis of elderly patients with arrhythmia and heart failure

作　　者：刘杰杰 舒亮辉 蒋薇[1] 隋利军 LIU Jie-jie;SHU Liang-hui;JIANG Wei;SUI Li-jun(Department of Cardiology, Wuxi Nineth Hospital, Soochow University, Wuxi 214000, China)

机构地区：[1]苏州大学附属无锡九院心内科,江苏省无锡市214000

出　　处：《实用老年医学》2022年第3期273-276,共4页Practical Geriatrics

基　　金：无锡市卫生计生委科研项目(Q201753)。

摘　　要：目的探究血清胱抑素C、hs-CRP预测老年心律失常心力衰竭(心衰)病人预后的效能。方法收集2016年12月至2020年5月我院收治的96例老年心律失常心衰病人的临床资料。根据治疗后出院随访12个月病人生存情况分为死亡组和生存组。比较2组血清胱抑素C、hs-CRP水平,并绘制ROC曲线分析胱抑素C、hs-CRP对老年心律失常心衰病人预后的预测价值。结果96例病人随访12个月,无失访者,28例死亡,68例存活;死亡组病人心功能分级Ⅲ~Ⅳ级占比、BNP、N末端脑钠肽前体(NT-proBNP)、LVEF水平明显高于存活组(P均<0.01);死亡组病人血清hs-CRP、胱抑素C水平均明显高于存活组(P均<0.05);老年心律失常心衰病人血清hs-CRP、胱抑素C与BNP、NT-proBNP、LVEF呈正相关(P均<0.05);ROC曲线显示血清胱抑素C和hs-CRP预测老年心律失常心衰病人预后的AUC分别为0.800(95%CI0.700~0.901)、0.635(95%CI0.515~0.754)。结论血清胱抑素C和hs-CRP对心律失常心衰病人预后具有一定的预测价值,血清胱抑素C预测更敏感。Objective To investigate the effects of serum cystatin C and high-sensitivity C-reactive protein(hs-CRP)in predicting the prognosis of the elderly patients with arrhythmia and heart failure.Methods The clinical data of 96 elderly patients with arrhythmia and heart failure admitted to our hospital from December 2016 to May 2020 were collected.They were divided into death group and survival group according to the survival of the patients after 12 months of follow-up after treatment.The levels of serum cystatin C and hs-CRP were compared between the two groups,and receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of cystatin C and hs-CRP for the prognosis of the elderly patients with arrhythmia and heart failure.Results All 96 patients were followed up for 12 months,and 28 patients died and 68 patients survived.The ratio of gradeⅢ-Ⅳof cardiac function and the levels of brain natriuretic peptide(BNP),N-terminal pro-brain natriuretic peptide(NT-proBNP),left ventricular ejection fraction(LVEF)in the death group were significantly higher than those in the survival group(all P<0.01);The levels of hs-CRP and cystatin C in the elderly patients were positively correlated with BNP,NT-proBNP and LVEF(all P<0.05).The area under the curve of serum cystatin C and hs-CRP for predicting the prognosis of the elderly patients with arrhythmia and heart failure was 0.800(95%CI 0.700-0.901)and 0.635(95%CI 0.515-0.754),respectively.Conclusions Serum cystatin C and hs-CRP have certain predictive value for the prognosis of the patients with arrhythmia and heart failure,and the sensitivity of serum cystatin C is higher.

关 键 词：胱抑素C 超敏C反应蛋白 老年人 心律失常 心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]