脓毒症相关凝血功能紊乱与免疫反应相关机制的研究进展  

Advance in sepsis-related coagulation disorders and immunity response

作　　者：李晋 王燕[1] 曾亚薇 王超[1] 齐文杰[1] Li Jin;Wang Yan;Zeng Yawei;Wang Chao;Qi Wenjie(Department of Infectious Diseases,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院感染内科,北京100050

出　　处：《中华危重病急救医学》2021年第12期1519-1523,共5页Chinese Critical Care Medicine

基　　金：首都卫生发展科研专项基金(首发2020-2-2027)。

摘　　要：凝血功能紊乱或弥散性血管内凝血(DIC)是一种以凝血与纤溶过程失衡为主要发病机制的临床病理综合征,全身微血栓形成与出血倾向是凝血功能紊乱的主要临床表现,其不良临床结局往往是诱发全身多器官功能障碍,脓毒症并发症DIC又显著增加了患者的病死率。而脓毒症相关凝血功能紊乱又与机体的炎症反应紧密相关。研究脓毒症相关凝血功能紊乱的发生机制,将为DIC的早期诊断及预后评估提供新的可能。现从免疫与炎症反应方面对脓毒症相关凝血功能紊乱机制的进展进行综述,以期为脓毒症相关凝血功能紊乱的治疗提供新的潜在靶点。Coagulation disorder or disseminated intravascular coagulation(DIC)is a clinicopathological syndrome,in which the imbalance between coagulation and fibrinolysis is the main pathogenesis,and systemic microthrombosis and systemic bleeding tendency are the main clinical manifestations.The clinical outcome is often the induction of systemic multiple organ dysfunction.As a common complication of sepsis,DIC significantly increases the mortality of septic patients.The coagulation disorder in sepsis is closely related to the inflammatory response of the body.Studying the mechanism of sepsis-related coagulation disorder will provide new possibilities for its early diagnosis and prognosis evaluation.This article reviews the latest research progress on the molecular mechanism of sepsis-related coagulation disorders in immunity and inflammation,in order to provide new possibilities for potential therapeutic targets.

关 键 词：脓毒症 凝血功能 弥散性血管内凝血 免疫 

分 类 号：R459.7[医药卫生—急诊医学]