果蝇造血器官淋巴腺的研究进展  

Research Progress of Hematopoietic Lymph Gland in Drosophila

作　　者：李坤 金丽华[1] LI Kun;JIN Lihua(College of Life Science,Northeast Forestry University,Harbin 150000,China)

机构地区：[1]东北林业大学生命科学学院,哈尔滨150000

出　　处：《生物技术进展》2022年第2期222-228,共7页Current Biotechnology

基　　金：国家自然科学基金项目(21964017)。

摘　　要：黑腹果蝇(Drosophilamelanogaster)是生物学研究中重要的模式生物之一。果蝇造血过程主要发生于胚胎和幼虫阶段,淋巴腺作为幼虫阶段的主要造血器官,由髓质区(medullaryzone,MZ)、皮质区(corticalzone,CZ)及后端信号中心区(posteriorsignalcenter,PSC)组成。淋巴腺在多种信号通路的调控下,能够维持血细胞的增殖和分化相对稳态,这对于果蝇的造血活动和正常生存均具有重要作用。综述了造血器官淋巴腺的形成过程及维持淋巴腺稳态的信号调节通路,以期为淋巴腺血细胞的详细分类和相应的功能研究奠定理论基础。Drosophila melanogaster is one of the important model organisms in biological research.The hemopoietic process of Drosophila mainly occurs during embryonic and larval stages.The lymph gland is the main hematopoietic organ in larval stage,which composed of medullary zone(MZ),cortical zone(CZ)and posterior signal center(PSC).A variety of signaling pathways plays a key role in regulating progenitor homeostasis in lymph glands.The relative steady state of blood cell is very important for the hematopoiesis and normal survival of Drosophila.This paper introduced the formation process of lymph gland and the signal pathway of maintaining lymph gland homeostasis,in order to lay a theoretical foundation for the detailed classification of lymph gland blood cells and the corresponding functional research.

关 键 词：果蝇 造血器官 淋巴腺 信号通路 

分 类 号：Q965[生物学—昆虫学]