骨桥蛋白、抗C1q抗体联合β_(2)-微球蛋白检测在狼疮性肾炎诊断中的应用价值  

Application value of osteopontin, anti-C1q antibody combined with β_(2)-microglobulin detection in the diagnosis of lupus nephritis

作　　者：赵婵媛 安沛欣 ZHAO Chanyuan;AN Peixin(Clinical Laboratory Department,Xi'an No.5 Hospital,Xi'an 710082,China)

机构地区：[1]西安市第五医院检验科,陕西西安710082

出　　处：《临床医学研究与实践》2022年第10期100-103,共4页Clinical Research and Practice

摘　　要：目的 研究骨桥蛋白(OPN)、抗C1q抗体联合β_(2)-微球蛋白(β_(2)-MG)检测在狼疮性肾炎(LN)诊断中的应用价值。方法 纳入2018年1月至2020年6月西安市第五医院收治的96例系统性红斑狼疮(SLE)患者为研究对象,根据是否合并LN将其分为非LN组(n=52)和LN组(n=44)。选取同期入院的40例其他免疫性疾病患者作为对照1组,40例健康体检者作为对照2组。比较四组的OPN、抗C1q抗体、β_(2)-MG和尿白蛋白水平。使用ROC曲线分析OPN、抗C1q抗体、β_(2)-MG单独及联合检测对LN的诊断价值。使用Pearson相关性分析LN患者OPN、抗C1q抗体、β_(2)-MG水平与尿白蛋白水平的相关性。结果 对照1组的OPN、抗C1q抗体、β_(2)-MG、尿白蛋白水平均明显高于对照2组(P<0.05);非LN组的OPN、抗C1q抗体、β_(2)-MG、尿白蛋白水平均明显高于对照1组和对照2组(P<0.05);LN组的OPN、抗C1q抗体、β_(2)-MG、尿白蛋白水平均明显高于非LN组、对照1组和对照2组(P<0.05)。OPN、抗C1q抗体联合β_(2)-MG诊断LN的AUC明显大于OPN、抗C1q抗体、β_(2)-MG单独检测和两两联合检测(P<0.05)。LN患者的OPN、抗C1q抗体、β_(2)-MG水平与尿白蛋白水平均呈明显正相关(P<0.05)。结论 OPN、抗C1q抗体联合β_(2)-MG检测能够明显提高对LN的诊断效能,且三者均与LN患者肾损伤程度具有明显的相关性。Objective To study the application value of osteopontin(OPN), anti-C1q antibody combined with β_(2)-microglobulin(β_(2)-MG) detecton in the diagnosis of lupus nephritis(LN). Methods Ninety-six patients with systemic lupus erythematosus(SLE) treated in Xi’an No.5 hospital from January 2018 to June 2020 were included as the research objects and divided into non-LN group(n=52) and LN group(n=44) according to whether they were combined with LN.Forty patients with other immune diseases admitted in the hospital during the same period were included as control group1, and 40 healthy people were included as control group 2. The levels of OPN, anti-C1q antibody, β_(2)-MG and urinary albumin in the four groups were compared. The diagnostic value of single and combined detection of OPN, anti-C1q antibody and β_(2)-MG for LN was analyzed by ROC curve. The correlation between OPN, anti-C1q antibody, β_(2)-MG levels and urinary albumin level in the LN patients were analyzed by Pearson correlation. Results The levels of OPN, anti-C1q antibody, β_(2)-MG and urinary albumin in the control group 1 were significantly higher than those in the control group 2(P <0.05);the levels of OPN, anti-C1q antibody, β_(2)-MG and urinary albumin in the non-LN group were significantly higher than those in the control group 1 and the control group 2(P<0.05);the levels of OPN, anti-C1q antibody, β_(2)-MG and urinary albumin in the LN group were significantly higher than those in the non-LN group, the control group 1 and the control group 2(P<0.05). The AUC of OPN, anti-C1q antibody combined with β_(2)-MG detection in the diagnosis of LN was significantly greater than that of OPN, anti-C1q antibody, β_(2)-MG alone and pairwise combined detection(P<0.05).OPN, anti-C1q antibody, β_(2)-MG levels were significantly positively correlated with urine albumin level in the LN patients(P<0.05). Conclusion OPN, anti-C1q antibody combined with β_(2)-MG detection can significantly improve the diagnostic efficiency of LN, and the three have significa

关 键 词：骨桥蛋白 抗C1Q抗体 β_(2)-微球蛋白 狼疮性肾炎 肾损伤 

分 类 号：R593.242[医药卫生—内科学]