BNP、CRP及CK-MB检测在川崎病患儿合并冠状动脉病变中的预测价值分析  

Values of BNP,CRP and CK-MB Detections in Prediction of Children with Kawasaki Disease Complicated by Coronary Artery Disease

作　　者：张亮[1] 徐玮玮[1] 郑钦亮 牛俊 宁君[1] ZHANG Liang;XU Wei-wei;ZHENG Qin-liang;NIU Jun;NING Jun(Department of Pediatrics,the Affiliated Hospital of Jining Medical College,Jining,Shandong 272001,China)

机构地区：[1]济宁医学院附属医院儿科,山东济宁272001

出　　处：《解放军医药杂志》2022年第3期69-72,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：2019年济宁医学院国家自然科学基金培育项目(JYP2019KJ32)。

摘　　要：目的分析脑利钠肽(BNP)、C反应蛋白(CRP)及心肌型肌酸激酶同工酶(CK-MB)检测在川崎病(KD)患儿合并冠状动脉病变中的预测价值。方法选取本院2017年1月—2021年7月收治的72例KD患儿,比较合并与未合并冠状动脉病变者BNP、CRP及CK-MB水平变化情况,不同冠状动脉病变严重程度(轻度、中度、冠状动脉瘤)KD患儿上述因子水平,并绘制受试者工作特征(ROC)曲线分析BNP、CRP及CK-MB联合检测对KD合并冠状动脉病变的预测价值。结果合并组BNP、CRP及CK-MB水平均明显高于未合并组(P<0.01)。轻度亚组BNP、CRP及CK-MB水平均显著低于中度、冠状动脉瘤亚组,中度亚组低于冠状动脉瘤亚组(P<0.05)。ROC曲线分析结果显示,BNP、CRP及CK-MB联合检测KD合并冠状动脉病变的曲线下面积、敏感度、特异度均明显高于单一检测。结论BNP、CRP及CK-MB与KD患儿合并冠状动脉病变严重程度密切相关,上述指标联合检测可提高对KD合并冠状动脉病变的预测价值。Objective To analyze values of brain natriuretic peptide(BNP),C-reactive protein(CRP)and myocardial creatine kinase isoenzyme(CK-MB)in prediction of children with Kawasaki disease(KD)complicated by coronary artery disease(CAD).Methods A total of 72 children with KD admitted between January 2017 and July 2021 were selected.Changes of BNP,CRP and CK-MB levels were compared between patients with and without CAD,and among KD children with different severity degrees of CAD(mild,moderate and coronary aneurysm).Receiver operating characteristic(ROC)curve was drawn to analyze the value of combined detection of BNP,CRP and CK-MB in prediction of KD complicated by CAD.Results Levels of BNP,CRP and CK-MB in combination group were significantly higher than those in non-combination group(P<0.01).Levels of BNP,CRP and CK-MB in mild subgroup were significantly lower than those in moderate and coronary aneurysm subgroups,and the levels in moderate subgroup were significantly lower than those in coronary aneurysm subgroup(P<0.05).ROC curve analysis showed that the area under the ROC curve,sensitivity and specificity of combined detection of BNP,CRP and CK-MB in children with KD complicated by CAD were significantly higher than those by single detections alone.Conclusion BNP,CRP and CK-MB are closely related to the severity of children with KD complicated by CAD.The combined detection of the above indexes may improve the predictive value of children with KD complicated by CAD.

关 键 词：黏膜皮肤淋巴结综合征 冠状动脉疾病 儿童 脑利钠肽 C反应蛋白 心肌型肌酸激酶同工酶 预测 

分 类 号：R725.4[医药卫生—儿科]