Hydrophilic polymer-coated PVC surface for reduced cell and bacterial adhesions  

作　　者：Rashed Almousa Xin Wen Sungsoo Na Gregory Anderson Dong Xie 

机构地区：[1]Weldon School of Biomedical Engineering,Purdue University,West Lafayette,Indiana,USA [2]Department of Medical Equipment Technology,College of Applied Medical Science,Majmaah University,Almajmaah,Saudi Arabia [3]Department of Biomedical Engineering,Purdue School of Engineering and Technology,Indiana University-Purdue University at Indianapolis,Indianapolis,Indiana,USA [4]Department of Biology,Purdue School of Science,Indiana University-Purdue University at Indianapolis,Indianapolis,Indiana,USA

出　　处：《Biosurface and Biotribology》2022年第1期34-43,共10页生物表面与生物摩擦学（英文）

摘　　要：Hydrophilic polymers are very useful in biomedical applications.In this study,biocom-patible polyethylene glycol(PEG)and polyvinylpyrrolidone(PVP)polymers end-capped with succinimidyl groups were either modified or synthesised and attached to poly-vinylchloride surfaces.The modified surfaces were evaluated with cell adhesion and bacterial adhesion.3T3 mouse fibroblast cells and three bacteria species were used to evaluate surface adhesion activity.Results showed that the modified surface exhibited significantly reduced 3T3 cell adhesion with a 50%-69%decrease for PEG and a 64%-81%for PVP,as compared to unmodified polyvinylchloride.The modified surface also showed significantly reduced bacterial attachment with 22%-78%,18%-76%and 20%-75%decrease for PEG and 22%-76%,18%-76%and 20%-73%for PVP to Staphy-lococcus aureus,Escherichia coli and Pseudomonas aeruginosa,respectively,as compared to unmodified polyvinylchloride.It seems that an appropriate chain length or molecular weight(neither the longest nor the shortest chain length)determines the lowest cell and bacterial adhesion in terms of PEG.On the other hand,a mixture of polymers with different chain lengths exhibited the lowest cell and bacterial adhesion in terms of PVP.

关 键 词：ADHESION BACTERIAL VIABILITY polymer POLYVINYLCHLORIDE SURFACE coating 

分 类 号：O63[理学—高分子化学]