Origin, evolution, and molecular function of DELLA proteins in plants  

作　　者：Huidan Xue Xiang Gao Peng He Guanghui Xiao 

机构地区：[1]College of Life Sciences,Shaanxi Normal University,Xi’an 710119,Shaanxi,China [2]School of Food and Biological Engineering,Shaanxi University of Science and Technology,Xi’an 710021,Shaanxi,China [3]School of Ecology and Environment,Northwestern Polytechnical University,Xi’an 710012,Shaanxi,China

出　　处：《The Crop Journal》2022年第2期287-299,共13页作物学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(32070549);Young Elite Scientists Sponsorship Program by CAST(2019-2021QNRC001);Shaanxi Youth Entrusted Talent Program(20190205);Fundamental Research Funds for the Central Universities(GK202002005);State Key Laboratory of Cotton Biology Open Fund(CB2020A12,CB2021A21,CB2021A05);the China Postdoctoral Science Foundation(2020M683549)。

摘　　要：Gibberellic acid(GA), a ubiquitous phytohormone, has various effects on regulators of plant growth and development. GAs promote growth by overcoming growth restraint mediated by DELLA proteins(DELLAs). DELLAs, in the GRAS family of plant-specific nuclear proteins, are nuclear transcriptional regulators harboring a unique N-terminal GA perception region for binding the GA receptor GIBBERELLIN INSENSITIVE DWARF1(GID1) and a C-terminal GRAS domain necessary for GA repression activity via interaction with multiple regulatory proteins. The N-terminal conserved region of DELLAs evolved to form a mode of GID1/DELLA-mediated GA signaling originating in bryophytes and ferns. Binding of GA to GID1 increases the affinity between DELLAs and a SCF E3 ubiquitin–ligase complex, thus promoting the eventual destruction of DELLAs by the 26 S proteasome. DELLAs negatively regulate GA response by releasing transcription factors to directly activate downstream genes and indirectly regulate GA biosynthesis genes increasing GA responsiveness and feedback control by promoting GID1 transcription. GA communicates extensively with other plant hormones and uses crosstalk to regulate plant growth and development. In this review, we summarize current understanding of evolutionary DELLA-mediated gibberellin signaling and functional diversification of DELLA, focusing primarily on interactions of DELLAs with diverse phytohormones.

关 键 词：DELLA proteins GA signaling pathway CROSS-TALK Plant hormone Growth and development 

分 类 号：Q946[生物学—植物学]