纳米氧化物对美托洛尔生物富集的影响研究  

Bioaccumulation of metoprolol in the presence of oxide nanoparticles

作　　者：卢媛[1] 宋琪 许佳瑶 孙红文[1] LU Yuan;SONG Qi;XU Jiayao;SUN Hongwen(College of Environmental Science and Engineering,Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria,Nankai University,Tianjin 300350,China;Panjin Campus of School of Foreign Languages,Dalian University of Technology,Panjin 124221,China;College of Environment,Shenyang University,Shenyang 110044,China)

机构地区：[1]南开大学环境科学与工程学院,环境污染过程与基准教育部重点实验室,天津300350 [2]大连理工大学外国语学院盘锦分院,辽宁盘锦124221 [3]沈阳大学环境学院,沈阳110044

出　　处：《农业环境科学学报》2022年第3期455-463,共9页Journal of Agro-Environment Science

基　　金：国家自然科学基金青年科学基金项目(42107447);南开大学大型仪器实验技术研发项目(21NKSYJS05)。

摘　　要：为揭示氧化物纳米颗粒(NPs)对离子型有机污染物在水生生物体内富集的影响,本研究考察了两种典型的氧化物NPs对鲤鱼富集β-阻断剂美托洛尔的影响以及美托洛尔在鱼体内各部位的分布,并通过批平衡实验进一步探讨了吸附解吸与生物富集的关系。结果表明:NPs共暴露时,在摄取阶段结束时美托洛尔生物浓缩因子(BCF)值增加了2.39倍(TiO;NPs)和3.49倍(SiO;NPs)。净化阶段鱼体内的美托洛尔半衰期由20.09 d缩短到8.39 d(TiO;NPs)和6.13 d(SiO;NPs),净化结束时鱼体内的美托洛尔残余浓度则略有升高。NPs的共暴露未改变鲤鱼摄取美托洛尔的途径,但显著升高了鱼鳃和内脏中美托洛尔的浓度。相对于TiO;NPs,SiO;NPs对美托洛尔具有更强的、且不可逆的吸附,使用Freundlich模型拟合的lg KF值分别为2.21(TiO;NPs)和4.47(SiO;NPs)。研究表明NPs能够通过吸附载带促进鱼体对美托洛尔的富集,吸附态美托洛尔主要通过摄食和鳃的呼吸作用随NPs进入鱼体内,由NPs携带进入鱼体内的美托洛尔一部分发生解吸从而被鱼体利用,未发生解吸的部分随NPs的排出被排出体外。To reveal the effect of oxide nanoparticles(NPs)on the bioaccumulation of ionic organic pollutants in aquatic organisms, the effects of two typical oxide NPs on the enrichment and distribution of the β-blocker metoprolol were investigated in carp(Cyprinus carpio).The relationship between adsorption/desorption and bioaccumulation was also examined through batch equilibrium experiments. At the end of the uptake phase, the bioconcentration factor(BCF)value had increased by 2.39 times(TiO;NPs)and 3.49 times(SiO;NPs). In the depuration phase, the half-life of metoprolol decreased from 20.09 d to 8.39 d(TiO;NPs)and 6.13 d(SiO;NPs). At the end of depuration,the residual concentration of metoprolol in carp increased slightly in the presence of NPs. Co-exposure to various types of NPs did not alter the method of metoprolol uptake by the carp;however, it did significantly increase the concentration of metoprolol in their gills and viscera.SiO;NPs exhibited a stronger and irreversible adsorption capacity for metoprolol compared to TiO;NPs;the lg KF values fitted by the Freundlich model were 2.21(TiO;NPs)and 4.47(SiO;NPs)respectively. Our results indicate that the presence of NPs promote the bioaccumulation of metoprolol in carp though sorption. Adsorbed metoprolol enters the body of the fish mainly via feeding and gill respiration;however, it is not completely desorbed or absorbed by the carp. Some associated metoprolol may be directly depurated from the body with the discharge of NPs.

关 键 词：纳米氧化物 美托洛尔 鲤鱼 生物富集 吸附/解吸 

分 类 号：X503.225[环境科学与工程—环境工程]