牛膝总皂苷在腰椎间盘突出症治疗中的研究进展  

Research progress of achyranthes bidentata saponin in the treatment of lumbar disc herniation

作　　者：张嘉麟 梁锦前[2] 刘宏哲[1] 刘向阳[1] 张明彦 袁龙辉 ZHANG Jialin;LIANG Jinqian;LIU Hongzhe;LIU Xiangyang;ZHANG Mingyan;YUAN longhui(Department of Orthopaedics,The First Affiliated Hospital of Hunan Normal University,The People's Hospital of Hunan Province,Changsha 410005;Department of Orthopaedics,Pecking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]湖南师范大学附属第一医院湖南省人民医院骨科,长沙410005 [2]中国医学科学院北京协和医学院北京协和医院骨科,北京100730

出　　处：《中华骨与关节外科杂志》2022年第2期150-154,共5页Chinese Journal of Bone and Joint Surgery

基　　金：湖南省卫生厅科技计划基金项目资助(B2014-086)。

摘　　要：近年来,由腰椎间盘突出症引起腰痛的人群呈年轻化趋势,药物保守治疗是腰椎间盘突出症的首选治疗方式。对牛膝主要成分牛膝总皂苷(ABS)的相关研究表明,ABS具有抗炎、抗细胞凋亡、保护软骨细胞等作用。同时,ABS在治疗腰椎间盘突出症所引起疼痛方面有着不可忽略的临床疗效。本文综述ABS的作用及其治疗腰椎间盘突出症的相关机制,以期为更好地利用ABS治疗腰椎间盘突出症提供有价值的参考。In recent years, people suffering from low back pain caused by lumbar disc herniation is becoming younger and younger,and conservative drug treatment is the preferred treatment for lumbar disc herniation. Studies related to the achyranthes bidentata saponin(ABS), the main component of achyranthes bidentata, have shown that ABS has anti-inflammatory, anti-apoptotic and chondrocyte protecting effects, and shows clinically effective in the treatment of pain caused by lumbar disc herniation. In this article the effects and the mechanisms of achyranthes bidentata saponin associated with lumbar disc herniation were introduced, with the aim of providing a valuable reference for the future use of achyranthes bidentata saponin in the treatment of lumbar disc herniation.

关 键 词：牛膝总皂苷 腰椎间盘突出 

分 类 号：R681.5[医药卫生—骨科学]