舒更葡糖钠用于先天性心脏病矫治术患儿超快通道麻醉的价值  

Value of sugammadex for ultra-fast-track anesthesia in pediatric patients undergoing surgery for correction of congenital heart disease

作　　者：姜燕 魏嵘[2] 张儒舫[3] 李小兵[3] 张瑞冬[1] 郑吉建[1] Jiang Yan;Wei Rong;Zhang Rufang;Li Xiaobing;Zhang Ruidong;Zheng Jijian(Department of Anesthesiology,Shanghai Children's Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Department of Anesthesiology,Shanghai Children's Hospital,Shanghai 200062,China;Department of Cardiothoracic Surgery,Shanghai Children's Hospital,Shanghai 200062,China)

机构地区：[1]上海交通大学医学院附属上海儿童医学中心麻醉科,200127 [2]上海市儿童医院麻醉科,200062 [3]上海市儿童医院心外科,200062

出　　处：《中华麻醉学杂志》2021年第12期1471-1474,共4页Chinese Journal of Anesthesiology

基　　金：吴阶平医学基金会临床科研专项资助基金(320.675018198)。

摘　　要：目的评价舒更葡糖钠用于先天性心脏病矫治术患儿超快通道麻醉的价值。方法择期行先天性心脏病矫治术患儿40例,性别不限,年龄1~6岁,ASA分级Ⅱ级。采用随机数字表法分为2组(n=20):舒更葡糖钠组(S组)和常规对照组(C组)。在麻醉恢复期,当TOF计数为0和强直刺激后计数(PTC)为1或2时,S组静脉注射舒更葡糖钠4.0 mg/kg,C组静脉注射相应容量的生理盐水,并记录从给药到TOF比值恢复至25%、75%和90%的时间、拔除气管导管时间以及超快通道麻醉达标情况。结果与C组比较,S组TOF比值恢复至25%、75%、90%的时间和拔除气管导管时间缩短(P<0.05),且超快通道麻醉的成功率为100%,而C组患儿均未达到超快通道麻醉的标准。结论舒更葡糖钠4.0 mg/kg静脉注射能明显缩短先天性心脏病矫治术患儿术后肌肉松弛恢复和拔除气管导管时间,并增加超快通道麻醉的成功率。Objective To evaluate the value of sugammadex for ultra-fast-track anesthesia in pediatric patients undergoing surgery for correction of congenital heart disease.Methods Forty pediatric patients of both sexes,aged 1-6 yr,with American Society of Anesthesiologists physical status Ⅱ,scheduled for elective surgery for correction of congenital heart disease,were enrolled in this study and randomly assigned into sugammadex group(group S)and control group(group C)with a random number table.Sugammadex 4.0 mg/kg was injected intravenously to reverse neuromuscular relaxation in group S and the equal volume of normal saline was administrated in group C when the train-of-four(TOF)count was 0 and post-tetanic count was 1 or 2 during recovery from anesthesia.The recovery time of TOF ratio to 25%,75% and 90%,the extubation time and the success rate of ultra-fast-track anesthesia were recorded.Results Compared to group C,sugammadex significantly shortened the recovery time of TOF ratio to 25%,75% and 90% and the extubation time in group S(P<0.05);Furthermore,the success rate of ultra-fast-track anesthesia reached 100% in group S compared to 0% in group C.Conclusion Intravenous administration of sugammadex 4.0 mg/kg significantly shortens the recovery time of neuromuscular relaxation and extubation time and enhances the success rate of ultra-fast-track anesthesia in pediatric patients undergoing surgical correction of congenital heart disease.

关 键 词：儿童 麻醉 全身 心脏缺损 先天性 舒更葡糖钠 

分 类 号：R726.1[医药卫生—儿科]