免疫抑制剂治疗肾移植术后复发性IgA肾病研究进展  

The progress of immunosuppressive therapy for IgA nephropathy patients underwent kidney transplantation

作　　者：董才韬 周大为[1] 梁峻滔 叶啟发[1,2] Dong Caitao;Zhou Dawei;Liang Juntao;Ye Qifa(Zhongnan Hospital of Wuhan University,Institute of Hepatobiliary Diseases of Wuhan University,Transplant Center of Wuhan University,National Quality Control Center for Donated Organ Procurement,Hubei Key Laboratory of Medical Technology on Transplantation,Hubei Clinical Research Center for Natural Polymer Biological Liver,Hubei Engineering Center of Natural Polymer-based Medical Materials,Wuhan 430071,China;The Third Xiangya Hospital of Central South University,Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology,Changsha 410013,China)

机构地区：[1]武汉大学中南医院,武汉大学肝胆疾病研究院,武汉大学移植医学中心,国家人体捐献器官获取质量控制中心,移植医学技术湖北省重点实验室,湖北省天然高分子生物肝临床医学研究中心,湖北省天然高分子基医用材料构建工程技术研究中心,430071 [2]中南大学湘雅三医院卫生部移植医学工程技术研究中心,长沙410013

出　　处：《中华移植杂志（电子版）》2021年第6期365-369,共5页Chinese Journal of Transplantation(Electronic Edition)

基　　金：国家自然科学基金(81970548);医学腾飞计划—“转化医学、医学+平台建设项目”(TFLC2018003);武汉市科技计划项目(2019020701011485)。

摘　　要：IgA肾病(IgAN)是常见的不可逆性自身免疫性疾病,随着病情进展可导致患者慢性肾功能衰竭,需要接受透析或肾移植治疗。IgAN患者肾移植术后复发是导致移植肾失功的主要原因之一。肾移植术后需持续服用免疫抑制剂,部分免疫抑制剂可能与IgAN发病相关,对IgAN患者肾移植术后施行个体化免疫抑制治疗可能会降低复发风险。本文对IgAN发病机制以及常见免疫抑制剂治疗肾移植术后复发性IgAN的作用机制进行综述。IgA nephropathy(IgAN)is the most common form of glomerulonephritis,and current evidence suggests that IgAN is the result of multiple sequential pathogenic hits and may led to end stage renal disease after diagnosis.However,IgAN has a strong tendency to recur in graft after kidney transplantation.In order to avoid graft loss due to IgAN recurrence,it is particularly important to provide sustained treatment for patients after kidney transplantation.Compared with the management of primary IgAN,not only can patients maintain previous treatment of primary IgAN after kidney transplantation,but also a wider range of immunosuppressive is available.The aim of this review is to describe the pathogenesis of IgAN and discuss the therapeutic mechanism of commonly used immunosuppressants for recurrent IgAN after kidney transplantation.

关 键 词：肾移植 IGA肾病 免疫抑制剂 复发 

分 类 号：R699.2[医药卫生—泌尿科学]