黑血动态增强核磁共振成像技术对早期动脉粥样硬化炎性反应的观察研究  

Study on the inflammatory response of early atherosclerosis by black blood dynamic enhanced MR technique

作　　者：赵龙[1] 董莉[1] 申强 郭淼[1] 杜志强 徐磊[1] 陈慧军[3] ZHAO Long;DONG Li;SHEN Qiang;GUO Miao;DU Zhiqiang;XU Lei;CHEN Huijun(Department of Radiology,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart,Lung and Blood Vessel Diseases,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所影像科,100029 [2]北京大学国际医院 [3]清华大学

出　　处：《心肺血管病杂志》2022年第2期197-201,共5页Journal of Cardiovascular and Pulmonary Diseases

基　　金：国家自然科学基金面上项目(81171335)。

摘　　要：目的:探索新型黑血动态增强核磁共振成像技术(BB DCE-MRI)在定量测量早期动脉粥样硬化炎症反应的价值。方法:20头,五指山小型猪,[3~4个月龄,雌雄不限,雄性已去势,体质量(29.29±1.25)kg]行高脂高TC饲养加球囊拉伤腹主动脉以制备动脉粥样硬化模型。对模型制备前后分别进行sfQIR黑血动态增强序列扫描(TR=750 ms;TE=12 ms;TI1=325ms;TI2=125 ms, ETL=8)。扫描2层,每层15幅图像。测量模型制备前、后的临床资料(TG、TC、HDL-C、LDL-C及胰岛素水平),并计算血管功能学指标血管壁容积传输常数(Ktrans),血浆容积(Vp),血管外细胞外容积(Ve),曲线下面积(AUC)。比较(1)模型制备前后临床资料与血管形态学、功能学的相关性;(2)模型制备前后临床资料差异与血管形态学、功能学差异的相关性。相关性分析应用Spearman相关分析,差异比较应用配对资料的符号检验进行统计分析。结果:TG及TC水平与血管壁Ktrans呈明显正相关(r=0.922,P=0.000;r=0.953,P=0.000)。胰岛素水平与AUC呈负相关(r=0.562,P=0.048)。同时发现TG、TC的变化与Ktrans变化有显著相关性(r=0.842,P=0.004;r=0.661,P=0.038)。结论:黑血DCE-MRI成像方法可以反映早期动脉粥样硬化斑块炎症特征,并与临床指标相一致。可以定量测量炎性反应的影像指标为早期动脉粥样硬化提供了一种无创的影像监测手段。Objective: To explore the value of black blood dynamic contrast enhanced MRI(BB DCEMRI) in quantitative measurement of early atherosclerotic inflammation. Methods: 20 wuzhishan swines [3-4 months of age, male and female, male castration(29.29 ± 1.25) kg] with high fat and cholesterol feeding and balloon injury in abdominal aortic atherosclerosis model preparation. SfQIR BB DCE-MRI scanning was performed before and after model preparation(TR=750 ms;TE=12 ms;TI1=325 ms;TI2= 25 ms, ETL = 8). Images of 2 layers with 15 images in each layer were obtained. Clinical data(triglyceride, cholesterol, high-density lipoprotein, low-density lipoprotein, and insulin levels) were measured before and after model preparation, and vascular functional indicators the volume transfer constant(Ktrans), total blood plasma volume(Vp), total extravascular extracellular space volume(Ve) and area under the curve(AUC) were calculated. The correlation between clinical data and vascular morphology and function before and after model preparation was compared. The correlation between the changes of clinical data and vascular morphology and function before and after model preparation was compared. Spearman correlation analysis was used for correlation analysis. Wilcoxon matched-pairs signed-ranks test was used for statistical analysis for the correlation between differences. Result: Triglyceride and cholesterol levels were positively correlated with Ktrans(R =0.922, P=0.000;R =0.953, P=0.000). Insulin level was negatively correlated with AUC(r=0.562, P=0.048). Changes of triglyceride and cholesterol were significantly correlated with the changes of Ktrans(R =0.842, P=0.004;R =0.661, P=0.038). Conclusions: Black Blood DCE-MRI imaging method can reflect the characteristics of the early atherosclerosis plaque inflammation, and is consistent with clinical indicators. Imaging indicators that can quantitatively measure the inflammatory response provide a noninvasive imaging monitoring method for early atherosclerosis.

关 键 词：磁共振成像 动态增强 动脉粥样硬化 斑块 炎症 

分 类 号：R54[医药卫生—心血管疾病]