小茴香茎叶水提液的抗炎镇痛作用研究  

Study on anti-inflammatory and analgesic effects of water extract of cumin

作　　者：王宵其 苏亚雯 韦馨惠 杨木生 陈学继 黄锁义 WANG xiao-qi;SU ya-wen;WEI xin-hui;YANG mu-sheng;CHEN xue-ji;HUANG Suo-yi(Youjiang Medical University for Nationalities,College of Pharmacy,Guangxi Baise b33000,China;Youjiang Medical University for Nationalities,College of Clinical Medicine,Guangxi Baise b33000,China;Youjiang Medical University for Nationalities,Science Experiment Center,Key Laboratory of Guangxi’s College for the Study of Characteristic Medicine in Youjiang River,Guangxi Baise b33000,China)

机构地区：[1]右江民族医学院药学院,广西百色533000 [2]右江民族医学院临床学院,广西百色533000 [3]右江民族医学院科学实验中心广西高校右江流域特色民族药研究重点实验室,广西百色533000

出　　处：《微量元素与健康研究》2022年第2期1-4,共4页Studies of Trace Elements and Health

基　　金：2018年国家级和自治区级大学生创新创业训练计划立项基金资助项目(No.201810599045);广西重点研发计划项目(No.桂科AB18221095);右江民族医学院高层次人才科研项目(No.01002018079)。

摘　　要：目的:评价小茴香水提液的抗炎、镇痛作用。方法:应用二甲苯致小鼠耳廓肿胀研究小茴香水提液的抗炎作用,采用热板法、甲醛法、醋酸致小鼠扭体反应研究小茴香水提液的镇痛作用。结果:小茴香水提液提取物各剂量组与模型组比较,能降低二甲苯所致小鼠的耳廓肿胀度(P<0.05);对热痛刺激的反应时间得到延缓(P<0.05);对甲醛所致的疼痛有一定的抑制作用(P<0.05);能减少醋酸所致的小鼠扭体反应次数,且与剂量呈一定的相关性(P<0.05)。结论:小茴香茎叶水提物具有抗炎镇痛作用。Objective: To evaluate the anti-inflammatory and analgesic effects of fennel water extract. Methods: The anti-inflammatory effect of fennel water extract was studied by ear swelling induced by xylene in mice;The e analgesic effect of fennel water extract was studied by hot plate method, formaldehyde method and acetic acid-induced writhing reaction in mice. Results: Compared with model group, fennel water extract could reduce the degree of auricle swelling induced by xylene(P<0.05). The reaction time to heat pain stimulus was delayed(P<0.05). It could inhibit the pain induced by formaldehyde(P<0.05). It can reduce the number of writhing reaction caused by acetic acid in mice, and has a certain correlation with the dose(P<0.05). Conclusions: Fennel stem and leaf water extract has anti-inflammatory and analgesic effects.

关 键 词：小茴香水提液 抗炎 镇痛 

分 类 号：X51[环境科学与工程—环境工程]