星点设计-效应面法优选陈皮健脾颗粒的成型工艺  

Study on the Optimization of Molding Process of Chenpi Jianpi Granules by Central Point Design-Response Surface Method

作　　者：陈卫卫 覃营[1,2] 唐雨菲 黄金成 李雨洋 刘相岑 CHEN Wei-wei;QIN Ying;TANG Yu-fei;HUANG Jin-cheng;LI Yu-yang;LIU Xiang-cen(Department of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China;Key Laboratory of Common Technology of Traditional Chinese Medicine Preparation in Universities of Guangxi,Guangxi University of Chinese Medicine,Nanning 530001,China)

机构地区：[1]广西中医药大学药学院,广西南宁530200 [2]广西中医药大学广西高校中药制剂共性技术研发重点实验室,广西南宁530001

出　　处：《现代中药研究与实践》2022年第1期62-66,共5页Research and Practice on Chinese Medicines

基　　金：广西中医药大学2019年自治区级大学生创新创业训练计划项目(201910600074);广西壮瑶药重点实验室(桂科基字[2014]32号);广西“2011协同创新中心”-壮瑶药协同创新中心(桂教科研[2013]20号);广西重点学科(壮药学)(桂教科研[2013]16号);广西第八批特聘专家项目(壮瑶药质量标准研究,桂人才通字[2019]13号);第一批“港澳台英才”入桂计划项目壮瑶药质量标准现代化研究(桂科智字[2019]42号);广西一流学科中药学(民族药学)(桂教科研[2018]12号);广西壮瑶医药与医养结合人才小高地(中共广西区委厅发[2017]44号)。

摘　　要：目的优选陈皮健脾颗粒的成型工艺。方法以稀释剂配比、稀释剂总用量为考察因素,以成型率、休止角及水分含量的总评"归一值"为评价指标,星点设计-效应面法优选陈皮健脾颗粒的成型工艺。结果干膏粉与稀释剂(糊精∶甘露醇=1∶1.5)按1∶3.5的比例混合均匀,加入75%乙醇制软材,干燥温度为65℃,干燥时间为2 h。结论优选的成型工艺稳定,制备的陈皮健脾颗粒合格率高、稳定性强、溶化性好,可为陈皮健脾颗粒的生产提供参考。Objective Optimizing the best forming process of Chenpi Jianpi granules.Methods Taking the proportion of diluent and the total amount of diluent as factors,and taking the“Overall desirability”of forming rate,angle of rest and water content as evaluation indexes,the central point design-response surface method is used to optimize the molding process of Chenpi Jianpi granules.Results Dry paste powder and diluent(dextrin:mannitol=1:1.5)are evenly mixed at a ratio of 1:3.5,and 75%ethanol is added to prepare soft material.The drying temperature is 65℃,the drying time is 2 h.Conclusion The optimized molding process is stable and the prepared Chenpi Jianpi granules are high qualification rate,strong stability and good solubility,which provide a reference for the production of Chenpi Jianpi granules.

关 键 词：陈皮健脾颗粒 成型工艺 星点设计-效应面法 

分 类 号：R283.6[医药卫生—中药学]