火针腧穴疗法对湿疹患者临床疗效及TGF-β1的影响  

Clinical Curative Effect of Fire Needle Acupoint Therapy on Patients with Eczema and the Influence on TGF-β1

作　　者：赵敏 陈洪强 熊大正 何彦柯 ZHAO Min;CHEN Hong-qiang;XIONG Da-zheng;HE Yan-ke(The Fifth People's Hospital of Zhuhai,Guangdong Zhuhai 519000)

机构地区：[1]珠海市第五人民医院,广东珠海519000

出　　处：《深圳中西医结合杂志》2022年第1期65-67,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广东省中医药局科研项目(20202178)。

摘　　要：目的:探究火针腧穴疗法对湿疹患者临床疗效及转化生长因子–β1(TGF–β1)的影响。方法:选取珠海市第五人民医院2019年8月至2020年10月期间收治的120例湿疹患者,随机分为对照组与观察组,各60例。两组患者均外涂丹皮酚软膏进行基础治疗。对照组患者在此基础上服用湿毒清胶囊,观察组患者在对照组基础上采用火针腧穴疗法进行治疗。观察两组患者在治疗前,治疗2周后、4周后的湿疹面积和严重程度指数评分表(EASI)评分、血清中TGF–β1及最小红斑量(MED)的变化情况。结果:与治疗前相比,两组患者在治疗2周后、4周后的EASI评分、TGF–β1均有不同程度下降,且观察组患者在治疗2周后、4周后的EASI评分、TGF–β1比对照组低,差异具有统计学意义(P<0.05)。与治疗前相比,两组患者在治疗2周后、4周后MED均不同程度增多,且观察组患者在治疗2周后、4周后MED比对照组多,差异具有统计学意义(P<0.05)。结论:火针腧穴疗法能有效改善湿疹患者的临床症状,对患者的病情恢复有积极作用。Objective To explore the clinical curative effect of fire needle acupoint therapy on patients with eczema,and the influence on transforming growth factor-β1(TGF-β1).Methods A total of 120 patients with eczema admitted to the Fifth People's Hospital of Zhuhai from August 2019 to October 2020 were selected,and randomly divided into a control group and an observation group,with 60 cases in each group.All patients were given treatment with external application of paeonol ointment.Patients in the control group were treated with shiduqing capsule,and patients in the observation group were treated with fire needle acupoint therapy on the basis of the natural group,the changes of eczema area,the eczema area and severity index EASI score,serum TGF-β1 and minimum erythema dose(MED)in the two groups before treatment and after 2 and 4 weeks after treatment were observed.Results Compared with before treatment,EASI score and TGF-β1 in the two groups decreased to varying degrees after 2 weeks and 4 weeks of treatment,and EASI score and TGF-β1 in the observation group were lower than those in the control group after 2 weeks and 4 weeks of treatment,the differences were statistically significant(P<0.05).Compared with before treatment,the MED of 2 weeks and 4 weeks increased to varying degrees,and the MED of 2 weeks and 4 weeks after treatment in the observation group was more than that of the control group,the difference was statistically significant(P<0.05).Conclusion Fire needle acupoint therapy can effectively improve the clinical symptoms of patients with eczema,with positive effect on recovery.

关 键 词：湿疹 火针疗法 湿毒清胶囊 丹皮酚软膏 

分 类 号：R246.7[医药卫生—针灸推拿学]