重组人干扰素联合常规三联雾化治疗婴幼儿病毒性肺炎的临床意义  

Clinical Significance of Recombinant Human Interferon Combined with Routine Triple Atomization in the Treatment of Infantile Viral Pneumonia

作　　者：颜思璐 高颖博 陈晓凡 YAN Si-lu;GAO Ying-bo;CHEN Xiao-fan(Guangzhou Baiyun District Maternity and Child Health Care Hospital,Guangdong Guangzhou 510410)

机构地区：[1]广州市白云区妇幼保健院,广东广州510410

出　　处：《深圳中西医结合杂志》2022年第1期116-119,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨重组人干扰素联合常规三联雾化治疗婴幼儿病毒性肺炎的临床价值。方法:选取2018年1月至2020年1月期间于广州市白云区妇幼保健院诊治的60例病毒性肺炎患儿为研究对象,按照随机数表法分为对照组和观察组。对照组30例,予以患儿基础治疗联合常规三联雾化,观察组30例,在对照组基础上加用重组人干扰素压缩雾化吸入,比较两组患儿临床症状消退时间、治疗前后血清炎症指标(肿瘤坏死因子–α、白细胞介素–6、白细胞介素–8),以及两组临床疗效和不良反应。结果:观察组咳嗽、喘憋、发热、肺啰音消退时间均短于对照组,临床治愈率高于对照组,治疗后各项血清炎症指标水平均低于对照组,差异均具有统计学意义(P<0.05),两组治疗期间均未见不良反应。结论:重组人干扰素联合常规三联雾化治疗婴幼儿病毒性肺炎,可以加速患儿临床症状消退,更好地改善炎症反应,效果优于单纯三联雾化,安全性高。Objective To explore the clinical value of recombinant human interferon combined with routine triple atomization in the treatment of infantile viral pneumonia.Methods A total of 60 children with viral pneumonia admitted to Guangzhou Baiyun District Maternity and Child Health Care Hospital from January 2018 to January 2020 were selected as the research objects,and they were randomly divided into a control group and an observation group.The 30 cases in the control group according to the random number table method,were given basic treatment combined with routine triple atomization;the 30 cases in the observation group were given the compressed atomization inhalation of recombinant human interferon on the basis of the control group.The clinical symptom regression time,serum inflammatory indexes(tumor necrosis factor-α,interleukin-6,interleukin-8)before and after treatment,as well as clinical efficacy and adverse reactions of the two groups were compared.Results The times of cough,wheezer,fever and pulmonary rales subsided in the observation group were shorter than those in the control group,the clinical cure rate was higher than that in the control group,and the levels of serum inflammatory indexes after treatment were lower than those in the control group,the differences were statistically significant(P<0.05).No adverse reactions were observed in the two groups during treatment.Conclusion Recombinant human interferon combined with routine triple nebulization in the treatment of infantile viral pneumonia can accelerate the subsidence of clinical symptoms in children and better improve the inflammatory response.The effect is superior to simple triple atomization and has high safety.

关 键 词：病毒性肺炎 常规三联雾化 重组人干扰素 儿童 

分 类 号：R725.6[医药卫生—儿科]