氨氯地平的临床药理及临床应用效果  

Clinical Pharmacology and Clinical Application of Amlodipine

作　　者：宋晓娜[1] SONG Xiaona(Shenyang School of Traditional Chinese Medicine,Shenyang 110300,China)

机构地区：[1]沈阳市中医药学校,辽宁沈阳110300

出　　处：《中国医药指南》2022年第10期85-88,共4页Guide of China Medicine

摘　　要：目的对氨氯地平的临床药理及临床应用效果进行分析。方法此次研究选取医院2018年2月至2019年1月收治的80例心血管疾病患者,进一步以随机数表法分成两组,其中对照组40例患者给予常规药物治疗,观察组40例患者则在常规药物治疗的基础上进一步使用氨氯地平治疗,治疗结束后比较两组患者的临床疗效、生活质量评分、用药不良反应的总发生率,并对氨氯地平的临床药理进行分析。结果①治疗后,观察组40例患者中,显效32例(80.00%)、有效6例(15.00%)、无效2例(5.00%);对照组40例患者,显效11例(27.50%)、有效19例(47.50%)、无效10例(25.00%)。观察组总有效率38例(95.00%),与对照组30例(75.00%)相比明显更高(P<0.05)。②治疗后,观察组的生活质量[生理功能、精神健康、躯体疼痛、情感职能、社会功能依次是(86.00±1.00)分、(80.00±1.00)分、(81.50±0.50)分、(83.00±1.00)分、(84.00±1.00)分]评分,与对照组生活质量[生理功能、精神健康、躯体疼痛、情感职能、社会功能依次是(70.50±0.50)分、(70.00±1.00)分、(71.50±1.00)分、(70.50±1.50)分、(71.50±0.50)分]评分相比明显更高(P<0.05)。③治疗后,观察组用药过程中出现恶心呕吐1例(2.50%)、头晕1例(2.50%),总发生率为2例(5.00%);对照组用药过程中出现恶心呕吐1例(2.50%)、头晕1例(2.50%)、嗜睡1例(2.50%),总发生率为3例(7.50%)。观察组的用药不良反应的总发生率与对照组比较,差异无统计学意义(P>0.05)。结论氨氯地平用于心血管疾病患者治疗的疗效尤为显著,且在降压、抗心力衰竭、缓解心绞痛方面的效果均较为理想,不良反应的总发生率较低,还能够提升患者的生活质量评分,安全且高效,值得推广。Objective The clinical pharmacology and clinical application of amlodipine were analyzed and discussed.Methods From February 2018 to January 2019,80 patients with cardiovascular disease in our hospital were selected,further divided into two different groups by the method of random numbers.In the control group,40 cases were treated with conventional drugs.In the observation group,40 patients were treated with amlodipine on the basis of routine drug therapy.After the end of the treatment,the clinical efficacy,quality of life score and total incidence of adverse drug reactions were compared between the two groups,the clinical pharmacology of amlodipine was analyzed.Results(1)After treatment,among the 40 patients in the observation group,32 cases(80.00%)were significantly effective,6 cases(15.00%)were effective,and 2 cases(5.00%)were ineffective.In the control group of 40 patients,11 cases(27.50%)were significantly effective,19 cases(47.50%)were effective and 10 cases(25.00%)were ineffective.The total effective rate in observation group was 38 cases(95.00%),which was significantly higher than that in control group 30 cases(75.00%)(P<0.05).(2)After treatment,the scores of quality of life[physical function,mental health,physical pain,emotional function,social function were(86.00±1.00)points,(80.00±1.00)points,(81.50±0.50)points,(83.00±1.00)points,(84.00±1.00)points],compared with the control group,the scores of quality of life[physiological function,mental health,physical pain,emotional function and social function were(70.50±0.50)points,(70.00±1.00)points,(70.50±1.50)points,(70.50±1.50)points,(71.50±0.50)points]were significantly higher(P<0.05).(3)After treatment,nausea and vomiting occurred in 1 case(2.50%)and dizziness occurred in 1 case(2.50%)in the observation group,with a total incidence of 2 cases(5.00%).In the control group,nausea and vomiting occurred in 1 case(2.50%),dizziness in 1 case(2.50%)and drowsiness in 1 case(2.50%),with a total incidence of 3 cases(7.50%).There was no significant difference

关 键 词：临床药理 氨氯地平 疗效 不良反应 心血管疾病 生活质量评分 

分 类 号：R969.3[医药卫生—药理学]