血小板型磷酸果糖激酶介导的代谢重编程机制及其在疾病中的作用研究进展  

Platelet isoform of phosphofructokinase-mediated metabolic reprogramming and roles in diseases:research progress

作　　者：王道辉 刘凤英 骆媛 王天[1] 王永安 WANG Dao-hui;LIU Feng-ying;LUO Yuan;WANG Tian;WANG Yong-an(Key Laboratory of Molecular Pharmacology and Drug Evaluation of Ministry of Education,School of Pharmacy,Yantai University,Yantai 264005,China;State Key Laboratory of Toxicology and Medical Countermeasures,Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China)

机构地区：[1]烟台大学药学院分子药理和药物评价教育部重点实验室,山东烟台264005 [2]军事科学院军事医学研究院毒物药物研究所,抗毒药物与毒理学国家重点实验室,北京100850

出　　处：《中国药理学与毒理学杂志》2022年第2期141-148,共8页Chinese Journal of Pharmacology and Toxicology

摘　　要：血小板型磷酸果糖激酶(PFKP)是细胞能量代谢糖酵解途径中重要的限速酶,在细胞内的表达保持动态平衡且相对稳定,发挥着调控细胞生物合成和能量代谢的作用,是代谢类疾病和癌症领域的研究热点。当细胞所处微环境发生变化时,如氧供应不足、代谢底物匮乏或细胞癌变时,细胞内出现PFKP介导的通过改变自身代谢模式而形成的代谢重编程,从而改善环境变化引起的不利影响;另一方面,PFKP在调控以Warburg效应为主的代谢模式中发挥重要作用,使代谢模式向糖酵解转移,形成有氧糖酵解方式。本文主要围绕PFKP介导的代谢重编程作用机制及其参与肿瘤、呼吸系统等疾病的病理生理机制和靶向治疗研究进展进行综述。The platelet isoform of phosphofructokinase(PFKP)is a key rate-limiting enzyme during glycolysis.It is stably expressed in cells and controls biosynthesis and energy metabolism.Consistently,PFKP has been a focus of study in metabolic diseases and cancer.On the one hand,when the cellular microenvironment changes,such as insufficient oxygen,metabolic substrate deprivation or cancera⁃tion,PFKP-mediated metabolic reprogramming will occur by changing metabolic patterns to ameliorate the negative effects.Furthermore,PFKP plays an important role in regulating the metabolic mode domi⁃nated by the Warburg effect,which shifts the metabolic mode to glycolysis and intensifies aerobic glycolysis.This review focuses on the mechanism by which PFKP mediates metabolic reprogramming and gets involved in the pathophysiology of diseases,such as cancer and respiratory diseases,while outlining the research progress in targeted therapy strategies.

关 键 词：血小板型磷酸果糖激酶 代谢重编程 肿瘤 糖酵解 细胞能量代谢 

分 类 号：Q55[生物学—生物化学] R963[医药卫生—微生物与生化药学]