母牛分枝杆菌菌苗超短程方案辅助治疗初治涂阴肺结核的远期效果  

Long-term efficacy of ultra-short-term antitubercular regimen and Mycobacterium vaccae vaccine in initial smear-negative pulmonary tuberculosis

作　　者：陈珣珣 陈亮 赖晓宇 林育齐 魏然 CHEN Xun-xun;CHEN Liang;LAI Xiao-yu;LIN Yu-qi;WEI Ran(Centre For Tuberculosis Control of Guangdong Province,Guangzhou 510630,China)

机构地区：[1]广东省结核病控制中心,广东广州510630

出　　处：《广东医科大学学报》2022年第1期31-33,共3页Journal of Guangdong Medical University

基　　金：“十三五”国家传染病科技重大专项基金资助项目(2018ZX10715004-002);广东省医学科学技术研究基金资助项目(C2019071)。

摘　　要：目的观察母牛分枝杆菌菌苗(以下称“微卡”)辅助治疗初治涂阴肺结核患者的远期效果。方法将已完成治疗的306例初治涂阴肺结核患者随访5 a,其中采用常规标准化6个月治疗的152例为对照组,常规标准化联合微卡超短程4个月治疗的154例为观察组,比较两组病灶恶化率与复发率。结果完成5 a随访的患者共137例(对照组79例,观察组58例),两组病灶恶化率与复发率差异无统计学意义(P>0.05)。结论微卡辅助治疗初治涂阴肺结核患者的远期疗效与常规治疗方案相似。Objective To observe the long-term efficacy of Mycobacterium vaccae vaccine in adjuvant treatment of patients with initial smear-negative pulmonary tuberculosis(PTB).Methods A total of 306 cases of initial smear-negative PTB who completed 6-month conventional treatment(control group,n=152)or 4-month conventional treatment and M.vaccae vaccine(observation group,n=154)were followed up for 5 years.The lesional deterioration and recurrence rates were compared between two groups.Results Only 137 patients completed the 5-year follow-up,including 79 cases in control group and 58 in observation group.The lesional deterioration and recurrence rates were comparable between two groups(P>0.05).Conclusion The long-term efficacy of M.vaccae vaccine adjuvant treatment is similar to that of conventional treatment regimen in patients with initial smear-negative PTB.

关 键 词：涂阴肺结核 微卡 远期疗效 

分 类 号：R183.3[医药卫生—流行病学] R521.5[医药卫生—公共卫生与预防医学]