Geranyl phenyl ethers from Illicium micranthum and their anti-HBV activity  

作　　者：LIU Yu YOU Yun-Xia RAO Li HE Qian SU Yu FAN Yue LI Yi-Zhou XU You-Kai ZHANG Chuan-Rui 

机构地区：[1]Chongqing Key Laboratory of Natural Product Synthesis and Drug Research,and Chemical Biology Research Center,School of Pharmaceutical Sciences,Chongqing University,Chongqing 401331,China [2]Key Laboratory of Tropical Plant Resource and Sustainable Use,Xishuangbanna Tropical Botanical Garden,Chinese Academy of Sciences,Menglun 666303,China [3]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China

出　　处：《Chinese Journal of Natural Medicines》2022年第2期139-147,共9页中国天然药物（英文版）

基　　金：supported by Chongqing Research and Frontier Technology(cstc2020jcyj-msxmX0537);the State Key Laboratory of Drug Research(SIMM1903KF-14);Fundamental Research Funds for the Central Universities(No.2020CDJ-LHZZ-006)。

摘　　要：Fourteen new geranyl phenyl ethers(1–14)along with three known compounds(15–17)were isolated from Illicium micranthum,and their structures were elucidated by comprehensive spectroscopic methods.Illimicranins A–H(1–8)were characterized as geranyl vanillin ethers,while 9 and 10 were dimethyl acetal derivatives.Illimicranins I and J(11 and 12)were rare geranyl isoeugenol ethers.Illimicranins K and L(13 and 14)represented the first example of geranyl guaiacylacetone ether and geranyl zingerone ether,respectively.Compounds 1,2 and 15 exhibited anti-HBV(hepatitis B virus)activity against HBsAg(hepatitis B surface antigen)and HBeAg(hepatitis B e antigen)secretion,and HBV DNA replication.

关 键 词：Illicium micranthum Geranyl phenyl ethers Spectroscopic data Anti-HBV activity 

分 类 号：R284.1[医药卫生—中药学] R965[医药卫生—中医学]