Dysideanones F—G and dysiherbols D—E,unusual sesquiterpene quinones with rearranged skeletons from the marine sponge Dysidea avara  

作　　者：LIU Hong-Yan ZHOU Mi SHANG Ru-Yi HONG Li-Li WANG Guang-Hui TIAN Wen-Jing JIAO Wei-Hua CHEN Hai-Feng LIN Hou-Wenu 

机构地区：[1]School of Pharmaceutical Sciences,Xiamen University,Xiamen 361102,China [2]Research Center for Marine Drugs,State Key Laboratory of Oncogene and Related Genes,Department of Pharmacy,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China

出　　处：《Chinese Journal of Natural Medicines》2022年第2期148-154,共7页中国天然药物（英文版）

基　　金：supported by the National Key Research and Development Program of China(No.2018YFC 0310900);the National Natural Science Foundation of China(Nos.U1605221,82022068,81773866,41906075,and 41576130)。

摘　　要：Four new sesquiterpene quinone meroterpenoids,dysideanones F—G(1—2)and dysiherbols D—E(3—4),were isolated from the marine sponge Dysidea avara collected from the South China Sea.The new structures were elucidated by extensive analysis of spectroscopic data including HR-MS and 1D and 2D NMR spectra,and their absolute configurations were assigned by single-crystal X-ray diffraction and ECD calculations.Anti-inflammatory evaluation showed that dysiherbols D—E(3—4)exhibited moderate inhibitory activity on TNF-α-induced NF-κB activation in human HEK-293T cells with IC_(50)values of 10.2 and 8.6μmol·L^(-1),respectively.

关 键 词：Dysidea avara Sesquiterpene quinones Marine sponge ANTI-INFLAMMATORY Marine natural products 

分 类 号：R284.1[医药卫生—中药学]